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文献和实验Hematopoietic Stem Cell Targeting with Surface-Engineered Lentiviral Vectors
Hematopoietic Stem Cell Targeting with Surface-Engineered Lentiviral Vectors Els Verhoeyen and François-Loïc Cosset Adapted from Gene Transfer: Delivery and Expression of DNA and RNA (eds. Friedmann and Rossi). CSHL Press, Cold
Cell Surface Engineering of Mesenchymal Stem Cells
; Blood 104:3581–3587, 2004). To address this challenge, we have developed a simple platform technology to chemically attach cell adhesion molecules to the cell surface to improve the homing efficiency to specific tissues. This chemical approach involves
Cell Cycle Checkpoint Control Mechanisms That Can Be Disrupted in Cancer
. Multiple checkpoints exist and are conserved in the cell cycle in higher eukaryotes to ensure that if one fails, others will take care of genomic integrity and cell survival. Many genes act as either positive or negative regulators of checkpoint function
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