IL-1RAcP/IL-1 R3 Protein, Mous

Expression of Uncoupling Proteins in a Mammalian Cell Culture System (HEK293) and Assessment of Their Protein Function

1 in the human embryonic kidney (HEK293) cell line are introduced. In isolated cell culture mitochondria, the proton leak can be measured and modulators of UCP1 activity can be tested. As mouse UCP1 in this system shows native behaviour, this may be a suitable

【热门靶点解析】IL-1功能解析、信号通路与靶向治疗进展

家族是一类重要的细胞因子，包含IL-1、IL-33和IL-36等多种成员，它们分别与不同受体结合，诱导受体与IL-1RAcP形成异聚体，招募MyD88启动信号级联反应，促进炎症基因表达。而IL-1家族受体(IL-1Rs)属于Ig样受体超家族，具有Toll/白细胞介素-1受体(TIR)结构域，与先天免疫反应相关。 IL-1的复杂生物学特性 IL-1是调控免疫与炎症的关键细胞因子，在肿瘤、自身免疫病及感染等疾病中发挥核心作用，并可诱导发热及激活HPA轴。其家族包括IL-1α和IL-1β，虽共享

Laboratory-Scale Purification of a Recombinant E-Cadherin-IgG Fc Fusion Protein That Provides a Cell Surface Matrix for Extended Culture and Efficient

human E-cadherin-IgG Fc domain fusion protein (E-cad-Fc) has recently been shown to be extremely efficient in facilitating the culture of human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells under completely defined conditions