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货号：463657
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文献和实验from that observed with thiolactomycin and triclosan, indicating that platensimycin selectively targets FabF/B. Similarly, titration of platensimycin using a S. aureus gel elongation assay, with octanoyl-CoA (C8:0) and malonyl-CoA as substrates, showed an IC~50
Gel-elongation assay for type II fatty acid synthesis
products, cerulenin (ref. 5) and thiolactomycin (ref. 6) which selectively inhibit the condensation enzymes FabH and FabF/B, were discovered more than two decades ago. New screening efforts and chemical modifications of existing compounds
Gel-elongation assay for type II fatty acid s
agent)(refs 3,4). Two natural products, cerulenin (ref. 5) and thiolactomycin (ref. 6) which selectively inhibit the condensation enzymes FabH and FabF/B, were discovered more than two decades ago. New screening efforts and chemical modifications
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