GC-7,150333-69-0

GC-7 产品活性：GC7 Sulfate 是一种脱氧嘌呤合成酶 (DHPS) 抑制剂。 产品来源： www.medchemexpress.cn/gc-7.html 研究领域：Cell Cycle/DNA Damage 作用靶点：DNA/RNA Synthesis In Vitro: The treatment of MYCN2 (±Dox) and BE(2)-C cells with GC7 for 72 h at various concentrations (0.1 to 100 μM) significantly reduces the number of viable cells in a dose-dependent manner. In MYCN2 cells, 5 μM of GC7 inhibits cell viability by ~40 and ~60 %, respectively, compare to untreated control cells. BE(2)-C cells require 25 μM of GC7 to reduce cell viability by ~50 %. Exposure to 10 and 100 μM GC7 for 72 h clearly decreases the levels of total retinoblastoma (Rb) and phosphorylated Rb as well as of Cdk4 protein, and increases the levels of p21 protein. Between 0 and 20 μM, GC7 induces little cytotoxicity in HCC cells, while higher concentrations of GC7 (50 to 100 μM) significantly inhibit the viability of all five HCC cell lines tested. Newly synthesized 3H-labeled hypusine of eIF5A1/eIF5A2 is rarely detected after 20 μM GC7 treatment, compare to untreated control. The activity of [3H]-spermidine incorporated into HCC cells is significantly decreased by 20 μM GC7 or higher concentration. 相关产品：Cycloheximide | Actinomycin D | Oxaliplatin | Gemcitabine | Bleomycin sulfate | Carboplatin | Mitomycin C | Cytarabine | 5-BrdU | Methotrexate | Streptozotocin | Anisomycin | Propidium Iodide | Fludarabine | ART558 | Thymidine | Hydroxyurea | Daunorubicin hydrochloride | Capecitabine | Remdesivir | Urolithin A | Brequinar | Folic acid | CX-5461 | Epirubicin hydrochloride | α-Amanitin | Branaplam | Plicamycin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。