AChE/BuChE-IN-5

AChE/BuChE-IN-5 产品活性：AChE/BuChE-IN-5 (compound 5a) 是一种双靶点抑制剂。AChE/BuChE-IN-5 对乙酰胆碱酯酶 (AChE) (IC50=46.9 nM) 和丁基胆碱酯酶 (BuChE) (IC50=3.5 nM) 具有良好的纳摩尔抑制活性。AChE/BuChE-IN-5 可用于阿尔茨海默病的研究。 产品来源： www.medchemexpress.cn/ache-buche-in-5.html 研究领域：Neuronal Signaling 作用靶点：Cholinesterase (ChE) In Vitro: AChE/BuChE-IN-5 inhibits acetylcholinesterase (AChE) (IC50=46.9 nM) and butyryl cholinesterase (BuChE) (IC50=46.9 nM) and shows better inhibitory effects than the known dual inhibitor Rivastigmine(HY-17368) in vivo animal model of AD disease. AChE/BuChE-IN-5 has a higher BuChE selectivity than AChE, and the selectivity index (SI) is 0.07, indicating that it has a stronger inhibitory effect on BuChE. In Vivo: AChE/BuChE-IN-5(1 mg/kg, ip.; 14 days) has neuroprotective, antioxidant and anti-apoptotic effects in AD animal models. 相关产品：Dimethyl sulfoxide | Donepezil Hydrochloride | TMPyP4 tosylate | Galanthamine | α-NETA | Physostigmine salicylate | Scopoletin | Rivastigmine | Garcinol | Imperatorin | sn-Glycero-3-phosphocholine | (-)-Huperzine A | Protopine | Protriptyline hydrochloride | Acetylcholinesterase, Fly head | Hemicholinium 3 | Tacrine | Timosaponin AIII | Demethoxycurcumin | Linarin | Tacrine hydrochloride | Pyridostigmine bromide | Corynoline | Epiberberine chloride | Isoimperatorin | Buntanetap | Corydaline | Sinapine thiocyanate 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。