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- 详细信息
- 文献和实验
- 技术资料
- 库存:
大量
- 英文名:
Pilocarpine nitrate salt
- CAS号:
148-72-1
- 保质期:
2年
- 供应商:
齐源生物
- 保存条件:
2-8℃
- 规格:
25g
属性
质量水平
100
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]25/D +83°, c = 10 in H2O(lit.)
颜色
white
溶解性
H2O: 100 mg/mL
SMILES字符串
O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
InChI
1S/C-11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
InChI key
PRZXEPJJHQYOGF-GNAZCLTHSA-N
基因信息
human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)
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文献和实验Effect of Argemone mexicana (L.) against lithium-pilocarpine induced status epilepticus and oxidative stress in Wistar rats.
G Asuntha et al.
Indian journal of experimental biology, 53(1), 31-35 (2015-02-14)
Argemone mexicana (L.) has a role in the treatment of epileptic disorders in Indian traditional system of medicine. We studied its effect on induced status epilepticus (SE) and oxidative stress in rats. SE was induced in male albino rats by
Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death.
Jin Hee Kim et al.
Brain research, 1499, 163-172 (2013-01-15)
The present study sought to evaluate the neuroprotective effects of apocynin, an NADPH oxidase assembly inhibitor, on seizure-induced neuronal death. Apocynin, also known as acetovanillone, is a natural organic compound isolated from the root of Canadian hemp (Apocynum cannabium). It
Sexual response in female rats with status epilepticus.
Tathiana A Alvarenga et al.
Epilepsia, 54(4), 644-648 (2013-02-13)
Female sexual function is complex and may be disrupted by disease, in particular epilepsy. Chronic seizures in women can have adverse effects on reproductive function, but it has been difficult to dissociate the effects of epilepsy from those related to
Three-dimensional evaluation of accommodating intraocular lens shift and alignment in vivo.
Susana Marcos et al.
Ophthalmology, 121(1), 45-55 (2013-08-21)
To quantify 3-dimensionally the anterior segment geometry, biometry, and lens position and alignment in patients before and after implantation of the Crystalens-AO (Bausch & Lomb, Rochester, NY) accommodating intraocular lens (A-IOL). Prospective, ob-servational study. Ten patients (20 eyes) with cataract
A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons.
Zechun Peng et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(36), 14392-14405 (2013-09-06)
Axonal sprouting of excitatory neurons is frequently ob-served in temporal lobe epilepsy, but the extent to which inhibitory interneurons undergo similar axonal reorganization remains unclear. The goal of this study was to determine whether somatostatin (SOM)-expressing neurons in stratum (s.)
A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus.
Jean-Baptiste Faure et al.
Epilepsia, 54(7), 1203-1213 (2013-05-15)
Administration of carisbamate during status epilepticus (SE) prevents the occurrence of motor seizures in the lithium-pilocarpine model and leads in a subpopulation of rats to spike-and-wave discharges characteristic of ab-sence epilepsy. Widespread neuroprotection accompanied this change in seizure expression. To
Brain recruitment of dendritic cells following Li-pilocarpine induced status epilepticus in adult rats.
Xiao-Wei Li et al.
Brain research bulletin, 91, 8-13 (2012-12-01)
Activation of inflammatory and immune pathways may contribute to the development of epilepsy. Dendritic cells (DCs), a heterogeneous group of professional antigen presenting cells, can be detected in the brain under several inflammatory conditions. However, the spatiotemporal distribution and origin
Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis.
Mi-Hyeon Jang et al.
Cell stem cell, 12(2), 215-223 (2013-02-12)
Adult neurogenesis, the process of generating mature neurons from adult neural stem cells, proceeds concurrently with ongoing neuronal circuit activity and is modulated by various physiological and pathological stimuli. The niche mechanism underlying the activity-dependent regulation of the sequential steps
Network Centrality of Resting-State fMRI in Primary Angle-Closure Glaucoma Before and After Surgery.
Fengqin Cai et al.
PloS one, 10(10), e0141389-e0141389 (2015-10-28)
Using voxel-wise degree centrality (DC), as measured by resting-state fMRI, we aimed to study alterations in the brain functional networks in patients with primary angle-closure glaucoma (PACG) and to reveal the plastic trajectories of surgery. A total of 23 preoperative
High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy.
Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
Effect of selective stimulation of muscarinic M3 cholinoceptors on electrical and contractile activity of rat ventricular myocardium.
D V Abramochkin et al.
Bulletin of experimental biology and medicine, 154(3), 295-298 (2013-03-14)
We studied the effect of selective activation of muscarinic M3receptors on electrical activity in the isolated preparation of rat ventricular myocardium as well as contractile activity of the left ventricle of Langendorff-perfused isolated heart. Application of muscarinic agonist pilocarpine (10(-5)M)
Alpha melanocyte stimulating hormone (α-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures.
Fernanda Rossatto Temp et al.
Life sciences, 93(20), 723-731 (2013-09-21)
Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated
鉴于HPLC应用在药品分析中越来越多,因此每一个药品分析人员应该掌握并应用HPLC。 I.概论 一、液相色谱理论发展简况 色谱法的分离原理是:溶于流动相(mobile phase)中的各组分经过固定相时,由于与固定相(stationaryphase)发生作用(吸附、分配、离子吸引、排阻、亲和)的大小、强弱不同,在固定相中滞留时间不同,从而先后从固定相中流出。又称为色层法、层析法。 色谱法最早是由俄国植物学家茨维特(Tswett)在1906年研究
0.05 0.003 微粒,µm滤器 0.22 0.2 微生物,CFU/ml 10 分三档 美国药典24版(2000年)要求TOC<0.5 mg/L(用标准蔗糖溶液1.19 mg/L),电导率在室温pH 6时≤2.4 µS/cm(即≥0.42 MΩ・cm)。HPLC级水
NCCLS ASTM 电阻率,MΩ·cm,25℃,最小 10.0 18.0 硅酸盐,mg/L,最大 0.05 0.003 微粒,µm滤器 0.22 0.2 微生物,CFU/ml 10 分三档 美国药典24版(2000年)要求TOC<0.5 mg/L(用标准蔗糖溶液1.19 mg/L),电导率在室温pH 6时≤2.4 µS/cm(即≥0.42 MΩ·cm)。HPLC级水增加吸收特性:在1cm池中,用超纯水作空白,在190nm、200nm和250~400nm的吸收
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