HPV16 E7/Protein E7 Antibody-H

HPV 并不是宫颈癌唯一的「元凶」？这种微生物化身「帮凶」，共同促进癌症发生

，同时进行了蛋白质的表达。 为了系统评估 hpv16 E6E7 整合和随后与沙眼梭菌合并感染对宿主调节的影响，研究人员从健康志愿者上分离出宫颈外干细胞，将其嵌入基质胶中培养 3D 类器官，并检测了来自各种 HPV 类型的 E6E7 基因。来自三个供体的子宫颈外器官检测 HPV 的 E6E7 癌基因均为阴性。这些来自健康供体的 HPV E6E7 阴性的类器官被用于研究 HPV 整合对健康宫颈组织的影响。 图片来源：Nature Communications 随后，研究人员用携带 HPV16 E6E7

Analysis of E7/Rb Associations

protein (pRb) via the ubiquitin pathway. pRb plays a key role in cell-cycle control by negatively regulating, via direct association, the activity of several transcription factors, including members of the E2F family. The neutralization of pRb functions

Selective Silencing of Viral Gene E6 and E7 Expression in HPV-Positive Human Cervical Carcinoma Cells Using Small Interfering RNAs

to target the respective viral mRNAs. E6 silencing induced accumulation of cellular p53 protein, trans activation of the cell cycle control p21 gene, and reduced cell growth. By contrast, E7 silencing induced apoptotic cell death. HPV-negative cells appeared