PROTAC ERRα ligand 2，2306388-5

ZBP1 降解新工具！南开大学团队开发共价 PROTAC

研究团队通过指数富集 (SELEX) 技术，针对 ZBP1 的 Zα 结构域筛选获得高亲和力 DNA 适配体 Z3，其与 ZBP1 的结合亲和力达到纳摩尔级，对 ZBP1 的结合力比其天然配体 Z-DNA 高出近 20 倍。   NASA 共价连接基团   在 linker 中引入 N-acyl-N-alkyl sulfonamide (NASA) 基团，使 PROTAC 能够与 ZBP1 上的亲核氨基酸残基形成稳定共价键，显著提升结合稳定性和降解效率

Ligand-Binding Assays for Collagen

Collagen is one of the most physiologically important agonists for platelet function. Two collagen-specific receptors, integrin α2 β1 and glycoprotein (GP) VI, have been identified on the platelet surface from studying patient’s platelets

Ligand-Binding Assays: Fibrinogen

The fibrinogen receptor on platelets is glycoprotein (GP) IIb/IIIa, also known as αIIb β3 . This receptor can bind to immobilized fibrinogen in its resting state. Binding to soluble fibrinogen, however, requires activation of the receptor