GSK3β inhibitor II，478482-75-6

A Conformationally Restricted -Strand HIV Protease Inhibitor

after the potent HIV protease inhibitor 2 , which together with a series of related derivatives was developed at Abbott Laboratories ( 11 ). This pseudopeptide contains a symmetrical diamino diol motif 8 (Fig. 2 ) flanked by Cbz-protected valine residues

v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平

andquantified ratios of phosphorylation relative to total proteinare provided. Figure 4.1b shows analysis of the same celllysates using phospho-β-catenin and p-CRMP2, two establishedtargets of GSK3. Note that only the phosphorylationof β-catenin is reduced

The Matrix Metalloproteinase (MMP) and Tissue Inhibitor of Metalloproteinase (TIMP) Genes: Transcriptional and Posttranscriptional Regulation, Signal

). This family of enzymes, which now contains twenty members, can collectively degrade all structural proteins of the ECM including interstitial collagens (I, II, III, and V), basement membrane collagens (IV), fibronectin, laminin, proteoglycan, and elastin