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- 文献和实验
- 技术资料
- 保存条件:
详询
- 保质期:
12 months from date of receipt.
- 英文名:
Mcl-1 inhibitor 14
- 库存:
99
- 供应商:
Biorbyt
- 规格:
5 mg/50 mg
| 规格: | 5 mg | 产品价格: | ¥0.0 |
|---|---|---|---|
| 规格: | 50 mg | 产品价格: | ¥0.0 |
描述: Mcl-1 inhibitor 14 (Ra-10) is a highly potent, sub-nanomolar inhibitor of myeloid cell leukemia-1 (MCL-1) with a Kᵢ of 0.018 nM. This compound is a valuable research tool for investigating MCL-1-dependent apoptosis and has demonstrated utility in both in vitro and in vivo models of cancer.
靶点: Others,Bcl-2 Family
分子式: C39H41ClFN5O5S
分子量: 746.29
研究领域: Cell Biology, Pharmacology & Drug Discovery; Cell Biology
保存条件: -20°C
备注: For research use only.
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文献和实验Differential Expression of Apoptosis-Associated Genes bax and bcl-2 in Ovarian Cancer
either as inhibitors (e.g., bcl-2, bcl-xl, mcl- 1) or promoters (e.g., bcl-xs, bax, bak, bad) of apoptosis (1 -3 ). The chromosomal translocation t(14;18), leading to overexpression of the Bcl-2 protein was first described in human B-cell lymphoma (4 ). Later
) and endonuclease-G (endo-G), from the mitochondria into the cytosol through a process that can be blocked by anti-apoptotic multi-domain Bcl-2 family members (Bcl-2, Bcl-xL, Bcl-w, Mcl-1, A1/Bfl1 and Bcl-B). Cytochrome c release is essential
[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
2-related) (MCL1), mRNA 961 NM_021959 Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 11 (PPP1R11), mRNA 462 NM_014730 Homo sapiens KIAA0152 gene product (KIAA0152), mRNA 713 NM_014402 Homo sapiens low molecular mass ubiquinone
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