2-tert-butoxycarbonyl-2-azabic

Synthesis of Peptidomimetic Conjugates of Cyclic Nucleoside Phosphonates

‐Ethyldiisopropylamine, (DIEA; Alfa Aesar), freshly distilled over KOH Amino acids or dipeptide: Methyl N ‐(tert ‐butoxycarbonyl

Synthesis of Building Blocks and Oligonucleotides with {G}O6‐Alkyl‐O6{G} Cross‐Links

Basic Protocol 3: Synthesis of 1‐{O6‐[3′‐O‐tert‐Butyldimethysilyl‐5′‐O‐Dimethoxytrityl‐N2‐Phenoxyacetyl‐2′‐Deoxyguanidyl]}‐7‐{O6‐[5′‐O‐Dimethoxytrityl‐N2‐Phenoxyacetyl‐2′‐Deoxyguanidyl‐3′‐O‐(β‐2‐Cyanoethyl‐N,N′‐Diisopropyl)Phosphoramidite]}‐Heptane

Using the SELEX Combinatorial Chemistry Process to Find High Affinity Nucleic Acid Ligands to Target Molecules

The SELEX (S ystematic E volution of L igands by EX ponential enrichments) combinatorial chemistry process is a procedure by which nucleic acid ligands of high affinity can be isolated against a molecular target (1 ). A wide variety