1-(1H-pyrazol-1-yl)cyclopropan

Two‐Step, One‐Pot Synthesis of Inosine, Guanosine, and 2′‐Deoxyguanosine O6‐Ethers via Intermediate O6‐(Benzotriazol‐1‐yl) Derivatives

for the etherification at the O 6 ?position of silyl?protected inosine, guanosine, and 2??deoxyguanosine is described. Typically, a THF solution of the silylated nucleoside is treated with 1H ?benzotriazol?1?yloxy?tris(dimethylamino)phosphonium hexafluorophosphate (BOP

Convenient and Efficient Approach to the Permanent or Reversible Conjugation of RNA and DNA Sequences with Functional Groups

of 3?,5??disilylated 2??O ?(methylthiomethyl)ribonucleosides to 2??O ?(phthalimidooxymethyl)ribonucleosides is achieved in yields of 66% to 94%. Desilylation and dephtalimidation of these ribonucleosides by treatment with NH4 F in MeOH produce 2??O ?aminooxymethylated

Synthesis of Peptide‐Oligonucleotide Conjugates by Diels‐Alder Cycloaddition in Water

in some cases to complete the reaction within 8 to 10 hr. Curr. Protoc. Nucleic Acid Chem. 31:4.32.1?4.32.31. © 2007 by John Wiley & Sons, Inc. Keywords: peptide?oligonucleotide conjugate; Diels?Alder cycloaddition; oligonucleotide synthesis