FLS-359,2309398-79-4

FLS-359 产品活性：FLS-359 是口服有效的 sirtuin 2 变构选择性调节剂，IC50 为 3 μM。FLS-359 通过抑制 DNA/RNA 复制，具有对 RNA 和 DNA 病毒的抗病毒活性。 产品来源： www.medchemexpress.cn/fls-359.html 研究领域：Cell Cycle/DNA Damage | Epigenetics 作用靶点：Sirtuin In Vitro: FLS-359 (0-100 μM) inhibits deacetylation of SIRT2 on a histone H3 site, with a substrate selectivity. FLS-359 inhibits growth of multiple RNA and DNA virus, like SARS-CoV-2, Influenza A, Hepatitis B, respiratory syncytial virus, with IC50 range of 0.3-6.7 μM. FLS-359 (0-10 μM, 24 h) inhibits the lytic activation of Epstein-Barr virus (EBV) in cells Akata, and the spread of human cytomegalovirus (HCMV) in diploid fibroblast with IC50 of 0.466 μM. FLS-359 (0-5 μM, 72 h) inhibits the accumulation of intracellular viral nucleic acids, the production of extracellular virus particles, and the infectivity of the virus particles. In Vivo: FLS-359 (50 mg/kg, p.o., single dose) exhibits a good plasma exposure with a plasma half-life of 6 h, maximal plasma concentrations Cmax of 89 μM and an AUC of 713 μM•h/mL. FLS-359 (50 mg/kg, p.o., twice daily for 11 days) inhibits HCMV infection in immunodeficient mice model. 相关产品：Nicotinamide | Resveratrol | Selisistat | Nicotinamide riboside chloride | 3-TYP | Fisetin | SRT 1720 | Suramin sodium salt | OSS_128167 | AGK2 | SRT 2104 | Sirtinol | UBCS039 | SIRT7 inhibitor 97491 | Thiomyristoyl | MC3482 | SirReal2 | Tenovin-6 | ADTL-SA1215 | Agrimol B | AK-7 | Cambinol | SRT 2183 | SRT 1460 | SIRT5 inhibitor 1 | SIRT6 activator 12q | CAY10602 | Ganoderic acid D | Perindopril erbumine