CDK2-IN-28,3025006-64-5

CDK2-IN-28 产品活性：CDK2-IN-28 (compound 22) 是一种 CDK2 抑制机，对其他 CDK 具有良好选择性和细胞效应。CDK2-IN-28 对 MKN1 细胞具有抗增殖作用 (EC50: 0.31 μM)， 产品来源： www.medchemexpress.cn/cdk2-in-28.html 研究领域：Cell Cycle/DNA Damage 作用靶点：CDK In Vitro: CDK2-IN-28 (37 nM-3 μM; 24 h) significantly down-regulates the level of Rb phosphorylation at Ser807/811 and Ser780 in MKN1 cells.CDK2-IN-28 (333.3 nM; 24 h) CDK2 inhibition in MKN1 cells causes cell cycle arrest in the G2/M phase. In Vivo: CDK2-IN-28 (10 mg/kg; po; single dose) provides poor plasma exposure in mouse, and CDK2-IN-28 (1 mg/kg; iv; single dose) also shows high plasma clearance (159-236 mL/min/kg) in mouse PK assay. 相关产品：Palbociclib | Abemaciclib | Ro-3306 | Ribociclib | Dinaciclib | GSK3326595 | Flavopiridol | (R)-Roscovitine | THZ1 | AZD4573 | THZ531 | SR-4835 | Kenpaullone | SY-5609 | Wogonin | GSK 3 Inhibitor IX | SNS-032 | Toyocamycin | Cirtuvivint | NVP-2 | Simurosertib | OTS964 hydrochloride | AT7519 | PF-07220060 | 5,6-Dichlorobenzimidazole riboside | Fadraciclib | JNJ-7706621