Nicardipine-d4盐酸尼卡地平-d4

Nicardipine-d4 hydrochloride 产品活性：Nicardipine-d4 hydrochloride 是氘代标记的 Nicardipine hydrochloride (HY-12515A)。Nicardipine hydrochloride (YC-93) 是一种钙通道 (calcium channel) 阻滞剂，可阻断心脏钙通道，IC50 为 1 μM。 Nicardipine hydrochloride 可用于研究慢性心绞痛以及控制血压。 产品来源： www.medchemexpress.cn/nicardipine-d4-hydrochloride.html 研究领域：Autophagy | Neuronal Signaling | Membrane Transporter/Ion Channel | Others 作用靶点：Autophagy | Calcium Channel | Isotope-Labeled Compounds In Vitro: Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.Nicardipine (0.1-10 μM; 24-48 h) reduces viability and proliferation of vascular smooth muscle cells (VSMCs) and inhibits their ability to migrate. In Vivo: Nicardipine (0.3-10 mg/kg; p.o.) shows antihypertensive properties. ? LD50s of Nicardipine are 643 mg/kg (oral) and 557 mg/kg (oral); 18.1 mg/kg (intravenous) 25.0 mg/kg (intravenous); 735 mg/kg (subcutaneous) and 683 mg/kg (subcutaneous); 171 mg/kg (intraperitoneally) and 155 mg/kg (intraperitoneally) for male and female Sprague-Dawley rats, respectively. ? LD50s of Nicardipine are 187 mg/kg (oral) and 15.5 mg/kg (intravenous) for male Wistar rats, respectively. ? LD50s of Nicardipine are 634 mg/kg (oral) and 650 mg/kg (oral); 20.7 mg/kg (intravenous) 19.9 mg/kg (intravenous); 540 mg/kg (subcutaneous) and 710 mg/kg (subcutaneous); 144 mg/kg (intraperitoneally) and 161 mg/kg (intraperitoneally) for male and female mice, respectively. 相关产品：Thapsigargin | Ionomycin | L-Ascorbic acid | Minocycline hydrochloride | Verapamil | 2-Aminoethyl diphenylborinate | Acetylcholine chloride | GSK1016790A | Nifedipine | Fasudil Hydrochloride | Ebselen | Halofuginone | Bay K 8644 | Carbamazepine | Tetrandrine | Ruthenium red | L-Phenylalanine | ISX-9 | Gabapentin | Amlodipine | CDN1163 | TPC2-A1-N | Ethacrynic acid | Cromolyn sodium | Dantrolene | Diltiazem hydrochloride | Taurolithocholic acid sodium salt