Baclofen-d5巴氯芬盐酸盐-d5,2012598-5

Baclofen-d5 hydrochloride 产品活性：Baclofen-d5 hydrochloride 是氘代标记的 Baclofen (HY-B0007)。Baclofen 是 γ-氨基丁酸 (GABA) 的亲脂性衍生物，是一种口服有效，选择性的代谢型 GABAB 受体 (GABABR) 激动剂。Baclofen 可以模拟 GABA 的作用并通过 GABAB 受体产生缓慢的突触前抑制。Baclofen 具有高的血脑屏障透过率。Baclofen 有用于肌肉痉挛研究的潜力。 产品来源： www.medchemexpress.cn/baclofen-d5-hydrochloride.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Others 作用靶点：GABA Receptor | Isotope-Labeled Compounds In Vitro: Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.Baclofen (1, 10 μM; 24 h) causes markedly decreased lactate dehydrogenase (LDH) activity, indicating increased cell viability in wild-type or mutant huntingtin-expressing striatal cells (HD19 or HD43). Baclofen significantly increases chymotrypsin-like proteasome activity and cell viability were in the HD43 cells. In Vivo: Baclofen (i.p.; 10 μg/g; twice daily for 3 consecutive days) ameliorates motor deficits in YAC128 HD transgenic mice. 相关产品：Bicuculline | γ-Aminobutyric acid | Picrotoxin | Aminooxyacetic acid hemihydrochloride | Propofol | Riluzole | Furosemide | Gabazine | Baclofen | Amentoflavone | Vigabatrin | CGP52432 | Flumazenil | Methionine | L-Lactic acid-13C3 sodium | Jujuboside A | L-Valine-d8 | L-Cycloserine | Etiocholanolone | THIP | Topiramate | Broflanilide | Tiagabine hydrochloride | 3-Indoleacetic acid-d5 | Muscimol | Sodium cyanoboronhydride-d3 | Clomethiazole