AChE-IN-62

AChE-IN-62 产品活性：AChE-IN-62 (Compound 1) 是一种有效的混合型选择性乙酰胆碱酯酶 (AChE) 抑制剂，IC50 值为 0.421 μM。AChE-IN-62 具有良好的血脑屏障透过性和神经保护作用。AChE-IN-62 能抑制 Aβ1?42 的聚集，IC50 值为 44.64 μM。AChE-IN-62 也是一种有效的多靶点定向配体 (MTDL)，可以用于阿尔兹海默症的研究。 产品来源： www.medchemexpress.cn/ache-in-62.html 研究领域：Neuronal Signaling 作用靶点：Cholinesterase (ChE) | Amyloid-β In Vitro: AChE-IN-62 (50 μM; 24-48 h) effectively inhibits the aggregation of Aβ1−42 with an IC50 value of 44.64 μM. AChE-IN-62 (5-20 μM; 24 h) demonstrates neuroprotective effects in SH-SY5Y and Neuro2A cells by ameliorating the neurotoxic effects mediated by H2O2 (200 μM; 24 h) and Okadaic acid (HY-N6785) (30 nM; 24 h). In Vivo: AChE-IN-62 (Compound 1) (10-20 mg/kg; i.p.; once daily for 7 days) improves the memory decline and learning disabilities induced by scopolamine (HY-N0296) (3 mg/kg; i.p.; once daily for 7 days) in Swiss albino mice with dementia by repairing the damage to the cortex and hippocampus, thus exerting a protective effect against the harm caused by scopolamine. 相关产品：Dimethyl sulfoxide | DAPT | β-Amyloid (25-35) | Thioflavin T | β-Amyloid (1-42), human TFA | FPS-ZM1 | Rutin | Colivelin TFA | Azeliragon | Santacruzamate A | 20(S)-Ginsenoside Rg3 | Ginsenoside Rg1 | β-Amyloid (1-42), (rat/mouse) | Donepezil Hydrochloride | Tolcapone | Methoxy-X04 | TMPyP4 tosylate | α-NETA | Aducanumab | Galanthamine | Physostigmine salicylate | Scopoletin | Garcinol | Rivastigmine | Geniposide | Notoginsenoside R1 | Semagacestat | Ginsenoside Re