Antitumor agent-153

Antitumor agent-153 产品活性：Antitumor agent-153 (compound 11b) 是基于 PRT4165 (HY-19817) 优化的 H2A 组蛋白泛素化抑制剂。Antitumor agent-153 可抑制人骨肉瘤 U2OS 细胞的活力并减少组蛋白 H2A 单泛素化，具有抗癌活性。 产品来源： www.medchemexpress.cn/antitumor-agent-153.html 研究领域：Metabolic Enzyme/Protease 作用靶点：E1/E2/E3 Enzyme In Vitro: Antitumor agent-153 has an IC50 of 5.86 μM on U2O cells and completely inhibits their proliferation at 30 μM .Reduced H2AK119ub1 levels disrupt tumor development and cancer cell growth. Antitumor agent-153 (24-96 μM; 1 h) can significantly reduce H2AK119ub1 levels in U2O cells in a dose-dependent manner. 相关产品：TAK-243 | Nutlin-3a | Subasumstat | Idasanutlin | Navtemadlin | Mezigdomide | ML-792 | PYR-41 | 2-D08 | MD-224 | C25-140 | Siremadlin | Cbl-b-IN-1 | RG7112 | HOIPIN-8 | Milademetan | Indole-3-carbinol | RB-3 | Ginkgolic Acid | LS-102 | Heclin | NSC697923 | Avadomide | PRT4165 | Alrizomadlin | NSC232003 | SZL P1-41 | BI8626 | BI8622