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Mouse LAG-3

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  • ¥1200 - 17600
  • SinoBio
  • 国产
  • CK56
  • 2025年12月22日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      蛋白表达区间:Ser23-Leu442

    • 保质期

      See instructions

    • 英文名

      标签:C-6His

    • 库存

      表达系统:Human Cells

    • 供应商

      上海经科化学科技有限公司

    • 规格

      10ug/50ug/500ug/1mg

    规格:10ug产品价格:¥1200.0
    规格:50ug产品价格:¥3520.0
    规格:500ug产品价格:¥12320.0
    规格:1mg产品价格:¥17600.0
    产品描述
    Recombinant Mouse Lymphocyte Activation Gene 3 Protein is produced by our Mammalian expression system and the target gene encoding Ser23-Leu442 is expressed with a 6His tag at the C-terminus.
    蛋白编号
    Q61790
    产品别称
    Lymphocyte activation gene 3 protein;CD223;Lag3
    偶联
    Unconjugated
    分子量
    46.2 KDa
    表观分子量
    55-80 KDa, reducing conditions
    剂型描述
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    内毒素
    < 1 EU/µg as determined by LAL test.
    纯度-SDS-PAGE
    Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
    复溶
    • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
    • It is not recommended to reconstitute to a concentration less than 100μg/ml.
    • Dissolve the lyophilized protein in distilled water.
    • Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
    运输条件
    • The product is shipped at ambient temperature.
    • Upon receipt, store it immediately at the temperature listed below.
    保存条件
    • Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
    • Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
    • Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
    产品背景
    Lymphocyte-activation gene 3 (LAG3), also known as CD223, is a type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4 and belongs to the immunoglobulin superfamily. The gene for LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20% identical to the CD4 gene. LAG3 is expressed on activated T cells, natural killer cells, B cells and plasmacytoid dendritic cells. LAG3 binds with high affinity to MHC class II molecules, and it interferes competitively with the binding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by this interaction. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and plays an important role in Treg suppressive function. LAG3 is the target of various drug development programs to develop new treatments for cancer and autoimmune disorders. The soluble form, sLAG-3, is being developed as a cancer drug.

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    图标文献和实验
    该产品被引用文献

    Lymphocyte-activation gene 3 (LAG3), also known as CD223, is a type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4 and belongs to the immunoglobulin superfamily. The gene for LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20% identical to the CD4 gene. LAG3 is expressed on activated T cells, natural killer cells, B cells and plasmacytoid dendritic cells. LAG3 binds with high affinity to MHC class II molecules, and it interferes competitively with the binding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by this interaction. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and plays an important role in Treg suppressive function. LAG3 is the target of various drug development programs to develop new treatments for cancer and autoimmune disorders. The soluble form, sLAG-3, is being developed as a cancer drug.

    相关实验
    • 停滞期 lag phase

         指细胞自移植于新培养基时起,至开始出现活跃繁殖的这一期间。一般被移植的细胞越是培养后期的,其停滞期越长。其原因是培养后期的细胞群在一定程度上进行同步化,而 G1 期的细胞比例高,进入分裂期需要时间;另外来自原培养期间所受的退行性变化的恢复也是重要的原因。  

    • 分离性迟延现象 segregation lag

      在突变发生的时候,由于细胞含有几个核(或是DNA的双链中只有一条链发生变化),所以要等细胞分裂几次以后,待一个细胞中的所有核(或DNA 的二条链)都是突变的核(或二条链都是突变链)的细胞分离出来的时候,突变性状才能表现出来,这种现象称为分离性迟延现象(如隐性突变的诱发)。  

    • 表现型延迟现象 phenotypic lag

         新获得的性状延迟表现的现象。一般诱变剂处理后所发生的突变需要经过好几个世代才能表现出细胞性状的变化。其原因可能有以下几种:( 1)基因虽然发生了突变,但在突变前所产生的物质未被耗尽之前细胞不会表现出突变的性状(例如大肠杆菌中从野生型变成甲硫氨酸缺陷型这种突变)。( 2)诱变剂本身并不是直接作用于 DNA,而是通过一系列的变化之后才能成为真正的诱变剂。( 3)诱变剂引起的 DNA的变化以及相应的突变确定( mutation fixation)是不同的两个过程

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    文献支持
    Mouse LAG-3
    ¥1200 - 17600