Human Siglec-2(CC09)产品图
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Human Siglec-2(CC09)

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  • ¥840 - 17600
  • SinoBio
  • 国产
  • CC09
  • 2026年04月30日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件:

      蛋白表达区间:Asp20-Arg687

    • 保质期:

      See instructions

    • 英文名:

      标签:C-Fc

    • 库存:

      表达系统:Human Cells

    • 供应商:

      上海经科化学科技有限公司

    • 规格:

      10ug/50ug/500ug/1mg

    规格:10ug产品价格:¥840.0
    规格:50ug产品价格:¥2520.0
    规格:500ug产品价格:¥12320.0
    规格:1mg产品价格:¥17600.0
    产品描述
    Recombinant Human B-cell Receptor CD22 is produced by our Mammalian expression system and the target gene encoding Asp20-Arg687 is expressed with a human IgG1 Fc tag at the C-terminus.
    蛋白编号
    P20273
    产品别称
    B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22 molecule; CD22; sialic acid binding Ig-like lectin 2; Siglec-2; SIGLEC2FLJ22814; T-cell surface antigen Leu-14
    偶联
    Unconjugated
    分子量
    102.3 KDa
    表观分子量
    120-150 KDa, reducing conditions
    剂型描述
    Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM EDTA, 150mM NaCl, pH 8.0 .
    内毒素
    < 1 EU/µg as determined by LAL test.
    纯度-SDS-PAGE
    Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
    生物活性-ELISA
    Immobilized Anti-Human Siglec-2 mAb(Cat#NC013) at 2μg/ml (100 μl/well)can bind Human Siglec-2-Fc(Cat#CC09).The ED50 of Human Siglec-2-Fc(Cat#CC09) is 24.05 ng/ml. (Regularly tested)
    复溶
    • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
    • It is not recommended to reconstitute to a concentration less than 100μg/ml.
    • Dissolve the lyophilized protein in distilled water.
    • Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
    运输条件
    • The product is shipped at ambient temperature.
    • Upon receipt, store it immediately at the temperature listed below.
    保存条件
    • Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
    • Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
    • Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
    产品背景
    Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or B-lymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec-2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec-2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.

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    图标文献和实验
    该产品被引用文献

    Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or B-lymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec-2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec-2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.

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      在免疫学研究的宏大版图中,糖生物学(Glycobiology)曾一度被视为“暗物质”——复杂且难以捉摸。然而,随着肿瘤免疫治疗进入瓶颈期,研究者们开始意识到,细胞表面那层被称为“糖萼(Glycocalyx)”的结构,并非仅仅是物理屏障,而是蕴含着极其精密的免疫调控逻辑。其中,Siglec(唾液酸结合免疫球蛋白样凝集素)家族凭借其对唾液酸(Sialic acid)信号的精准解码能力,正迅速成为继 PD-1/PD-L1 之后,免疫检查点研究领域的又一个核心焦点。   对于试图在这一领域寻找突破

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    Human Siglec-2(CC09)
    ¥840 - 17600