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- 2025年11月09日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
蛋白表达区间:Ser67Leu202
- 保质期：
See instructions
- 英文名：
标签:Tag free
- 库存：
表达系统:E.coli
- 供应商：
上海经科化学科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥630.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥1890.0 |
| 规格： | 500ug | 产品价格： | ￥11970.0 |
| 规格： | 1mg | 产品价格： | ￥18000.0 |
- Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
- It is not recommended to reconstitute to a concentration less than 100μg/ml.
- Dissolve the lyophilized protein in distilled water.
- Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- The product is shipped at ambient temperature.
- Upon receipt, store it immediately at the temperature listed below.
- Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
- Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
- Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
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文献和实验Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.
，表现为炎症蛋白的增加和脑源性神经营养因子等生长因子的减少。不过，脑脊液中的这些变化是否与年龄相关的认知能力下降有关尚不清楚。 2022 年 5 月 11 日，来自斯坦福大学医学院神经学与神经科学系的科研团队在国际顶级期刊 Nature 发表了题为 Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17 的研究性文章，他们发现将年轻的脑脊液直接注入衰老的大脑可以明显改善记忆功能，其中少突胶质细胞对这种恢复
FGFR-AP-FGF Binding Assay, PCR Assays for Knockout Mice, RNase Protection Assay:The bound receptor was quantified by measuring the initial rate of substrate hydrolysis at 405 nm and same amount of proteins was used in the binding assays... 完整的实验方法请
for nutrient and waste exchange between the fetus and its mother. The trophoblast can be modeled in vitro using trophoblast stem cells. Trophoblast stem cells require fibroblast growth factor (FGF)4, heparin, and contact with embryonic fibroblasts
技术资料