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- 2025年07月08日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
for future use below -18°C
- 保质期：
See instructions
- 英文名：
ACE2 (18-740), Fc
- 库存：
常规产品有备货
- 供应商：
上海经科化学科技有限公司
- CAS号：
无
- 规格：
50ug/150ug/250ug
| 规格： | 50ug | 产品价格： | ￥14500.0 |
|---|---|---|---|
| 规格： | 150ug | 产品价格： | ￥35500.0 |
| 规格： | 250ug | 产品价格： | ￥50715.0 |
CATALOGUE NUMBER
ENZ-1126
INTRODUCTION
ACE-2 (Angiotensin converting enzyme 2) an enzyme bound to cell membranes in various organs such as intestines arteries , lungs, heart & kidney. ACE2 an entry receptor of SARS coronaviruses as well as SARS-CoV-2,.The coronavirus spike (S) glycoprotein is a class I viral fusion antigen located on the external envelope of the virion that takes part in a critical part in viral infection by identifying host cell receptors and facilitating fusion of the viral and cellular membranes. 2 main domains in coronavirus S1 have been recognized, the N-terminal domain and C-terminal domain. One or the other and/or both S1 domains function as a receptor-binding domain. SARS-CoV + M.E/R.S-CoV equally use C-domain to attach their receptors.ACE2 is a type I transmembrane antigen with an extracellular N-terminal domain having the catalytic site and an intracellular C-terminal tail. ACE2 obtains a signal peptide, a transmembrane domain, and a single metalloproteinase active site containing an HEXXH zinc-binding domain. ACE-2 plays a role as a mono-carboxypeptidase which degrades Ang I to produce the nonapeptide Ang 1–9 and Ang II to create the heptapeptide Ang 1–7.
DESCRIPTION
The HEK293 derived ACE2 Human recombinant protein contains the amino acids 18-740 fused to Fc tag at C-terminal. ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
SOURCE
HEK293 Cells
PURIFICATION METHOD
Purified by Protein-G chromatographic technique.
PHYSICAL APPEARANCE
FORMULATION
ACE2 Human protein solution is supplied in 50mM Tris-HCl, pH7.5, and 150mM NaCl and glycerol.
STABILITY
ACE-2 Human Recombinant Protein is shipped on ice packs. Upon arrival, Store at -20°C.
PURITY
ACE-2 Protein is >95% pure as determined SDS-PAGE.
BIOLOGICAL ACTIVITY
ACE2 activity was measured by its binding ability in a functional ELISA.
The immobilized Recombinant Human ACE2 protein binds to SARS CoV2 Spike protein Receptor Binding Domain at 2ug per ml.
SAFETY DATA SHEET
SDS
USAGE
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文献和实验The HEK293 derived ACE2 Human recombinant protein contains the amino acids 18-740 fused to Fc tag at C-terminal. ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
技术资料