Amino-dPEG®-Tris(-dPEG®-Tris(m

Amino-dPEG®-Tris(-dPEG®-Tris(m-dPEG®))-25mg，Amino-dPEG®₂₄-Tris(-dPEG®₂₄-Tris(m-dPEG®₂₄)₃)₃-25 mg，Amino-dPEG®-Tris(-dPEG®-Tris(m-dPEG®))-25mg,Amino-dPEG®₂₄-Tris(-dPEG®₂₄-Tris(m-dPEG®₂₄)₃)₃-25 mg

Amino-dPEG®-Tris(-dPEG®-Tris(m-dPEG®))-25mg-Amino-dPEG®₂₄-Tris(-dPEG®₂₄-Tris(m-dPEG®₂₄)₃)₃-25 mg

产品货号：CCT-QBD-11486-25

产品规格：25mg

Amino-dPEG®24-Tris(-dPEG®24-Tris(m-dPEG®24)3)3，产品编号QBD-11486，是一种九支化、15.4 kDa聚乙二醇化试剂，由高纯度、单分子量、离散PEG(dPEG®)化合物围绕tris核构建。连接点是羧酸盐反应性伯胺。九个不带电荷的甲氧基封端的dPEG®24接头形成分支。九个分支点以1：3的排列从四个tris核产生。从伯胺连接点到末端甲氧基的平均dPEG®间隔基长度为241个原子(155.1个)。本产品设计用于生物分子偶联，以调节生物分子(如抗体或其他蛋白质)的药代动力学(PK)和生物分布(BD)。它也可用于钝化表面以防止非特异性相互作用。Amino-dPEG®24-Tris(-dPEG®24-Tris(m-dPEG®24)3)3(产品号QBD-11486)中的游离伯胺为dPEG®构建体提供了与羧酸酯或羧酸的活性酯(NHS酯、TFP酯)连接的唯一连接点，从而形成稳定的酰胺键。羧酸酯或活性酯可以在生物分子(蛋白质、蛋白质片段或肽)或表面(例如，用羧酸或其活性酯官能化的纳米颗粒)上。胺还与醛反应，醛可以在糖蛋白的碳水化合物涂层上产生。胺和醛反应形成不稳定的席夫碱，其在温和条件下容易还原以产生稳定的仲胺。当使用Amino-dPEG®24-Tris(-dPEG®24-Tris(m-dPEG®24)3)3修饰带电生物分子时，用户应注意不带电荷的甲基可能会改变缀合物的总电荷。

Amino-dPEG®24-Tris(-dPEG®24-Tris(m-dPEG®24)3)3, product number QBD-11486, is a nine-branched, 15.4 kDa, PEGylation reagent built around tris cores from high-purity, single molecular weight, discrete PEG (dPEG®) compounds. The attachment point is a carboxylate-reactive primary amine. Nine uncharged methoxy-terminated dPEG®24 linkers form the branches. The nine branch points arise from four tris cores in a 1:3 arrangement. The average dPEG® spacer length from the primary amine attachment point to the terminal methoxy groups is 241 atoms (155.1 Å). This product is designed for biomolecular conjugation to modulate the pharmacokinetics (PK) and biodistribution (BD) of biomolecules such as antibodies or other proteins. It may also be used to passivate surfaces to prevent non-specific interactions.PEGylation of biomolecules with Amino-dPEG®24-Tris(-dPEG®24-Tris(m-dPEG®24)3)3 greatly increases a conjugate molecule's hydrodynamic volume and water solubility and shields the conjugate from opsonization by the immune system. These effects prevent renal clearance of the conjugate by the body and reduce or eliminate opsonization, extending the conjugate's serum half-life. The longer serum half-life can lead to lower dosing requirements for the PEGylated conjugate compared to the non-PEGylated conjugate while maintaining diagnostic or therapeutic efficacy.Vector Laboratories' dPEG® technology uses high-purity, single molecular-weight PEG linkers and spacers with discrete chain lengths. In contrast, traditional, non-uniform polymer PEG linkers and spacers have an intractable mixture of different chain lengths of PEG, where each length of PEG in the mix has a unique molecular weight. Analyzing dPEG® products and conjugates made with them is far more straightforward than analyzing non-uniform PEG products and their conjugates.The free primary amine in Amino-dPEG®24-Tris(-dPEG®24-Tris(m-dPEG®24)3)3, product number QBD-11486, provides the sole attachment point for the dPEG® construct to connect with a carboxylate or the active ester (NHS ester, TFP ester) of a carboxylic acid, forming a stable amide bond. The carboxylate or active ester can be on a biomolecule (protein, protein fragment, or peptide) or surface (for example, nanoparticles functionalized with carboxylic acids or their active esters). The amine also reacts with aldehydes, which can be generated on the carbohydrate coats of glycoproteins. The amine and aldehyde reaction forms a labile Schiff base, which readily reduces under mild conditions to create a stable secondary amine. When using Amino-dPEG®24-Tris(-dPEG®24-Tris(m-dPEG®24)3)3 to modify charged biomolecules, users should be aware that the uncharged methyl groups likely will alter the overall charge of the conjugate.

Amino-dPEG®-Tris(-dPEG®-Tris(m-dPEG®))-25mg-Amino-dPEG®₂₄-Tris(-dPEG®₂₄-Tris(m-dPEG®₂₄)₃)₃-25 mg

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