Broomoacetamido-dPEG ®-Tris(-d

Broomoacetamido-dPEG ®-Tris(-dPEG®-broomacetamide)-100mg，Bromoacetamido-dPEG®₁₂-Tris(-dPEG®₁₁-bromoacetamide)₃-100 mg，Broomoacetamido-dPEG ®-Tris(-dPEG®-broomacetamide)-100mg,Bromoacetamido-dPEG®₁₂-Tris(-dPEG®₁₁-bromoacetamide)₃-100 mg

Broomoacetamido-dPEG ®-Tris(-dPEG®-broomacetamide)-100mg-Bromoacetamido-dPEG®₁₂-Tris(-dPEG®₁₁-bromoacetamide)₃-100 mg

产品货号：CCT-QBD-11434-100

产品规格：100mg

硫醇-马来酰亚胺反应，也称为硫醇-迈克尔加成，是一种点击化学反应。这种强大的，非常受欢迎的反应被广泛用于生物共轭应用。在pH 6.5 - 7.5时，硫醇-马来酰亚胺反应是化学选择性的。然而，在pH 7.5以上，马来酰亚胺基团与胺竞争性反应，因此pH应保持在该限度以下。溴乙酰胺基-dPEG ®12-三(-dPEG®11-酰胺基-溴乙酰胺)3，产品编号QBD-11434，是一种支链、单分子量、硫醇反应性、离散聚乙二醇(dPEG®)产品。它被设计为通过硫醇-溴乙酰基反应连接多达四个分子。四个臂中的每一个连接到中心三核，并终止于硫醇反应性溴乙酰基。从溴乙酰基基团之间通过tris核的dPEG®间隔基长度为87个原子(100.0 μ π ι)。

Bromoacetamido-dPEG®12-Tris(-dPEG®11-amido-bromoacetamide)3, product number QBD-11434, is a branched, single molecular weight, thiol-reactive, discrete polyethylene glycol (dPEG®) product. It is designed to join up to four molecules via a thiol-bromoacetyl reaction. Each of the four arms attaches to a central tris core and terminates with a thiol-reactive bromoacetyl group. The dPEG® spacer length from between the bromoacetyl groups through the tris core is 87 atoms (100.0 Å). Like the thiol-maleimide reaction, the thiol-bromoacetyl reaction forms stable thioether bonds with free thiols. However, maleimides react optimally at pH 6.5 - 7.5, while bromoacetyl groups react with thiols chemoselectively at pH =8.0. Moreover, thioether bonds formed from a thiol-maleimide reaction can sometimes undergo a reverse Michael addition, undoing the thioether bond. This does not happen with thioether bonds formed by a thiol-bromoacetyl reaction. The thiol-bromoacetyl reaction is chemoselective for thiols but slightly less selective than the thiol-maleimide reaction.Unlike traditional polyethylene glycol (PEG), which are non-uniform, dispersed polymers, Vector Laboratories' dPEG® products are single molecular weight PEGs with discrete chain lengths, hence the dPEG® name. The four arms of MAL-dPEG®12-Tris(-dPEG®11-amido-MAL)3 are built around a core of tris(hydroxymethyl)aminomethane ("tris"). Although one arm is structured a little differently than the other three arms (one dPEG®12 arm vs. three dPEG®11 arms), the product is essentially symmetrical through the tris core. This precise construction of Bromoacetamido-dPEG®12-Tris(-dPEG®11-amido-bromoacetamide)3 is possible because of Vector Laboratories' dPEG® technology. This product can link multiple peptides or proteins together for drug delivery. It could also be used as a core unit for constructing dendrimers with precisely defined spacer lengths.

Broomoacetamido-dPEG ®-Tris(-dPEG®-broomacetamide)-100mg-Bromoacetamido-dPEG®₁₂-Tris(-dPEG®₁₁-bromoacetamide)₃-100 mg

点击：Broomoacetamido-dPEG ®-Tris(-dPEG®-broomacetamide)-100mg-Bromoacetamido-dPEG®₁₂-Tris(-dPEG®₁₁-bromoacetamide)₃-100 mg查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多Vectorlabs公司Azides（Biotin-Azides）试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。，请点击查看艾美捷特色产品中心。