TFP-dPEG ®-(m-dPEG ®)-ester-10

TFP-dPEG ®-(m-dPEG ®)-ester-100 mg，TFP-dPEG®₄-(m-dPEG®₁₁)₃-ester-100 mg，TFP-dPEG ®-(m-dPEG ®)-ester-100 mg,TFP-dPEG®₄-(m-dPEG®₁₁)₃-ester-100 mg

TFP-dPEG ®-(m-dPEG ®)-ester-100 mg-TFP-dPEG®₄-(m-dPEG®₁₁)₃-ester-100 mg

产品货号：CCT-QBD-11401-100

产品规格：100mg

TFP-dPEG®4-(m-dPEG®11)3酯，产品编号QBD-11401，是一种水溶性、胺反应性、离散PEG(dPEG®)聚乙二醇化试剂。该产物围绕tris核构建，并且由均匀(即，单分散的)PEG 4尾部和三个(3)中等长度(35个原子)的分支，由甲基封端的dPEG®11(m-dPEG®11)构成。从反应性末端到甲基末端的总dPEG®间隔基长度为63个原子(平均74.1个原子)。TFP-dPEG®4-(m-dPEG®11)3酯用于聚乙二醇化和修饰胺反应性生物分子和表面。这种亲水性支链dPEG®产品大大增加了缀合物的流体动力学体积，降低了免疫原性和肾清除率。此外，该产品减少或消除与缀合物和表面的非特异性结合。

TFP-dPEG®4-(m-dPEG®11)3 ester, product number QBD-11401, is a water-soluble, amine-reactive, discrete PEG (dPEG®) PEGylation reagent built. This product is built around a tris core and consists of a short (21 atoms) amine-reactive 2,3,5,6-tetrafluorophenyl (TFP) ester "tail" on a uniform (i.e., monodispersed) PEG4 tail and three (3) medium-length (35 atoms) branches composed from methyl-terminated dPEG®11 (m-dPEG®11). The total dPEG® spacer length from the reactive end to the methyl termini is 63 atoms (74.1 Å average). TFP-dPEG®4-(m-dPEG®11)3 ester is used to PEGylate and modify amine-reactive biomolecules and surfaces. This hydrophilic branched dPEG® product greatly increases the conjugates' hydrodynamic volumes, reducing immunogenicity and renal clearance. Moreover, this product reduces or eliminates non-specific binding to conjugates and surfaces.TFP esters react with free amines like NHS esters to form stable amide bonds. TFP esters' optimal reaction pH is 7.5 - 8.0, which is higher than NHS esters (optimal pH range 7.0 - 7.5). However, published research has shown that, within the optimal reaction pH range, TFP esters are more reactive toward amines than NHS esters are within their optimal pH range. Applications for TFP-dPEG®4-(m-dPEG®11)3 ester, product number QBD-11401, include the following:conjugating proteins and other biomolecules to modify PK and BD;PEGylating amine-coated surfaces (e.g., nanoparticles) to sterically shield the surfaces and reduce non-specific, hydrophobic interactions;PEGylating amine-coated organic or inorganic surfaces (e.g., carbon, gold, silver nanoparticles) to reduce or eliminate immunogenicity;PEGylating biomolecules to reduce renal clearance and increase serum half-life; andPEGylating biomolecules to reduce immunogenicity and increase water solubility.

TFP-dPEG ®-(m-dPEG ®)-ester-100 mg-TFP-dPEG®₄-(m-dPEG®₁₁)₃-ester-100 mg

点击：TFP-dPEG ®-(m-dPEG ®)-ester-100 mg-TFP-dPEG®₄-(m-dPEG®₁₁)₃-ester-100 mg查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多Vectorlabs公司Azides（Biotin-Azides）试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。，请点击查看艾美捷特色产品中心。