Bromoacetamido-dPEG®-酰胺DBCO-25

Bromoacetamido-dPEG®-酰胺DBCO-25mg，Bromoacetamido-dPEG®₁₂-amido-DBCO-25 mg，Bromoacetamido-dPEG®-酰胺DBCO-25mg,Bromoacetamido-dPEG®₁₂-amido-DBCO-25 mg

Bromoacetamido-dPEG®-酰胺DBCO-25mg-Bromoacetamido-dPEG®₁₂-amido-DBCO-25 mg

产品货号：CCT-QBD-11223-25

产品规格：25mg

溴乙酰胺基-dPEG ®12-酰胺基-DBCO，产品编号11223，将硫醇反应性溴乙酰基与二苄基环辛炔(DBCO，也称为DIBAC)(一种无铜点击化学反应性基团)组合。两个反应性基团通过中等长度(40个原子，46.1 μ m)、柔性、单分子量、离散聚乙二醇(dPEG®)接头连接。溴乙酰基在pH = 8.0时与硫醇发生化学选择性反应。这与马来酰亚胺基团不同，马来酰亚胺基团在pH 6.5 - 7.5范围内与巯基化学选择性反应。DBCO部分是在任一侧上侧接两个苄基环的应变环辛炔环。DBCO被设计用于应变促进的叠氮化物-炔环加成(SPAAC)，也称为无铜点击化学。

Bromoacetamido-dPEG®12-amido-DBCO, product number 11223, combines a thiol-reactive bromoacetyl group with dibenzylcyclooctyne (DBCO, also known as DIBAC), a copper-free click chemistry reactive group. The two reactive groups link via a medium-length (40 atoms, 46.1 Å), flexible, single molecular weight, discrete polyethylene glycol (dPEG®) linker. The bromoacetyl group reacts chemoselectively with thiols at pH = 8.0. This differs from the maleimide group, which reacts chemoselectively with sulfhydryls within the range of pH 6.5 – 7.5. The DBCO moiety is a strained cyclooctyne ring flanked by two benzyl rings on either side. DBCO was designed for strain promoted azide-alkyne cycloaddition (SPAAC), also known as copper-free click chemistry.

Bromoacetamido-dPEG®-酰胺DBCO-25mg-Bromoacetamido-dPEG®₁₂-amido-DBCO-25 mg

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