DBCO-dPEG MAL-25mg-DBCO-dPEG®₂

DBCO-dPEG MAL-25mg，DBCO-dPEG®₂₄-MAL-25 mg，DBCO-dPEG MAL-25mg,DBCO-dPEG®₂₄-MAL-25 mg

DBCO-dPEG MAL-25mg-DBCO-dPEG®₂₄-MAL-25 mg

产品货号：CCT-QBD-10594-25

产品规格：25mg

DBCO-dPEG®12-MAL，产品编号QBD-10593，是一种中等长度(54个原子)、单分子量、离散聚乙二醇(dPEG®)交联剂。二苄基环辛炔(DBCO)部分允许应变促进的叠氮化物-炔环加成(SPAAC)，也称为“无铜点击化学”。“马来酰亚胺丙基(MAL)官能团与巯基形成硫醇-醚键。单分子量dPEG®间隔基是亲水性的且非免疫原性的。DBCO-dPEG®12-MAL提供了PEG的优点(增加的水溶性、无免疫原性)，而没有PEG分散性的分析难题。

DBCO-dPEG®24-MAL, product number QBD-10594, is a long (90 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) crosslinking reagent. The dibenzylcyclooctyne (DBCO) moiety permits strain promoted azide-alkyne cycloaddition (SPAAC), also known as "copper free click chemistry." The maleimidopropyl (MAL) functional group forms a thiol-ether linkage with sulfhydryl groups. The hydrophilic, non-immunogenic dPEG® spacer in DBCO-dPEG®24-MAL provides the benefits of PEG (increased water solubility, non-immunogenicity) without the analytical headaches of PEG dispersity.The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) discovered by K. Barry Sharpless and coworkers is one of the best known click chemistry reactions, but its in vivo usability is limited by copper toxicity. Carolyn Bertozzi and coworkers developed SPAAC as a way to avoid copper’s toxic effects on living cells using a highly strained cyclooctyne. Developments since the initial publication show that reagents based on DBCO provide excellent, highly selective reactivity with azides, forming a triazole product.Maleimide groups are widely popular for their ability to react rapidly with sulfhydryl groups via a Michael addition to form thioether bonds.Vector Laboratories' dPEG® products clearly differ from traditional, polymeric polyethylene glycol (PEG). Traditional PEG is a disperse polymer product with a Poisson distribution of chain lengths and molecular weights. The intractable mixture of chain lengths and molecular weights in traditional PEG products creates significant analytical challenges. In contrast, Vector Laboratories' dPEG® products are single molecular weight compounds with discrete chain lengths. Using Vector Laboratories' products greatly simplifies analysis of dPEG®-conjugated compounds.

DBCO-dPEG MAL-25mg-DBCO-dPEG®₂₄-MAL-25 mg

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