Azido-dPEG® Amine-1000mg-Azido

Azido-dPEG® Amine-1000mg，Azido-dPEG®₃₅-amine-1000 mg，Azido-dPEG® Amine-1000mg,Azido-dPEG®₃₅-amine-1000 mg

Azido-dPEG® Amine-1000mg-Azido-dPEG®₃₅-amine-1000 mg

产品货号：CCT-QBD-10526-1000

产品规格：1000mg

叠氮基-dPEG ®35-胺，产品编号QBD-10526，是一种羰基反应性生物相容性交联剂，可参与多种类型的反应。该产品由长(107个原子)、单分子量、离散聚乙二醇(dPEG®)链两端的叠氮基和胺基组成。炔与叠氮基在金属催化或应变促进的点击化学中反应以产生三唑衍生物。此外，叠氮基用作掩蔽的胺，其经由合适的还原剂还原成伯胺。此外，叠氮基-dPEG ®35-胺可参与与适当膦衍生物的施陶丁格连接以产生水溶性产物。

Azido-dPEG®35-amine, product number QBD-10526, is a carbonyl-reactive, biocompatible crosslinking reagent that can participate in multiple types of reactions. The product consists of azide and amine groups on opposite ends of a long (107 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) chain. Alkynes react with the azido group in metal-catalyzed or strain-promoted click chemistry to yield triazole derivatives. Moreover, the azide group functions as a masked amine that reduces to a primary amine via a suitable reducing agent. Furthermore, Azido-dPEG®35-amine can participate in a Staudinger ligation with appropriate phosphine derivatives to create a water-soluble product.The amphiphilic dPEG® product adds hydrodynamic volume and imparts water solubility to any compound to which it is conjugated. Also, because the terminal azide group functions in multiple different types of reactions, Azido-dPEG®35-amine can act as either a heterobifunctional, click chemistry crosslinker or a monoprotected homobifunctional crosslinking reagent. As a heterobifunctional click chemistry reagent, the azide group reacts with alkynes to form triazoles. The amino terminus of the molecule then can react with carboxylic acids, aldehydes, or ketones to crosslink the conjugate to another molecule. As a monoprotected homobifunctional crosslinker, the amine end reacts first with carboxylic acids (or their active esters), aldehydes, or ketones, leaving the azide end of the molecule free. The reduction of the azido group with a suitable reducing agent, such as triphenylphosphine, yields a free amine that can be conjugated similarly to the conjugation of the first amine group. Reacting the amine groups with aldehydes or ketones results in labile Schiff bases that should be reduced to secondary amines for bond stability.

Azido-dPEG® Amine-1000mg-Azido-dPEG®₃₅-amine-1000 mg

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