m-dPEG ® MAL-100mg-m-dPEG®₁₂-M

m-dPEG ® MAL-100mg，m-dPEG®₁₂-MAL-100 mg，m-dPEG ® MAL-100mg,m-dPEG®₁₂-MAL-100 mg

m-dPEG ® MAL-100mg-m-dPEG®₁₂-MAL-100 mg

产品货号：CCT-QBD-10289-100

产品规格：100mg

m-dPEG®12-MAL，产品编号QBD-10289，是一种巯基反应性、单分子量、具有离散链长的PEG(dPEG®)。该产品通过马来酰亚胺反应基团用游离巯基修饰表面和生物分子。非免疫原性的甲基封端的dPEG®链不带电荷，但增加了与其缀合的分子的水溶性和流体动力学体积。

m-dPEG®12-MAL, product number QBD-10289, is a sulfhydryl-reactive, single molecular weight, with a discrete chain length PEG (dPEG®). This product modifies surfaces and biomolecules with free thiol groups through the maleimide reactive group. The non-immunogenic, methyl-terminated dPEG® chain has no charge but adds water solubility and hydrodynamic volume to molecules to which it is conjugated.The reaction of the maleimide end of m-dPEG®12-MAL, product number QBD-10289, with a sulfhydryl proceeds best at pH 6.5 – 7.5. Conduct the conjugation at the lowest reasonable pH within this range. Above pH 7.5, free amines compete with free thiols at the maleimide reaction site, which creates confusing results. Moreover, at higher pH values, the maleimide ring may open to form unreactive maleamic acid.Published uses for m-dPEG®12-MAL include probing the molecular structure and function of proteins and coating nanoparticle surfaces. In particular, studies of molecular structure and function of proteins would not be possible with traditional, dispersed PEG products because the dispersed PEGs would have created an indecipherable mixture of conjugation products. Only a dPEG® product could work in this application.

m-dPEG ® MAL-100mg-m-dPEG®₁₂-MAL-100 mg

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