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- 2025年12月05日
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产品活性：Tubulin polymerization-IN-46 (compound 9q) 是微管蛋白 (Microtubule/Tubulin) 抑制剂，抑制微管蛋白的聚合和诱导细胞凋亡 (apoptosis)。Tubulin polymerization-IN-46 抑制有丝分裂，将 MCF-7 细胞阻滞于 G2/M 期。Tubulin polymerization-IN-46 对 MCF-7 乳腺癌细胞具有抗增殖活性，IC50 为 10 nM。
产品来源： www.medchemexpress.cn/tubulin-polymerization-in-46.html
研究领域：Cell Cycle/DNA Damage | Cytoskeleton
作用靶点：Microtubule/Tubulin
In Vitro: Tubulin polymerization-IN-46 (compound 9q) (0.5 μM; 16 h) induces depolymerization of the microtubule network in MCF-7 breast cancer cells.
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文献和实验Tubulin Polymerization with GTP/GMPCPP/Taxol
GMPCPP and add a small volume of the seeds (~1/20-1/50 vol) after the polymerization mix has been at 37¡C for 1'. Axonemes or centrosomes can also be used as nucleating structures. If the purpose is labeling or recycling the tubulin, polymerization
Locomotion of leukocytes is a complex event requiring coordinated activity of cytoskeletal, membrane, and adhesion systems (1 ). Prior to the migration of cells into the inflamed tissue, they have to pass the endothelium. This process
SDS Gel Electrophoresis of Tubulin\MAPs
. Scan the gels or photographically analyze them. Determine the molecular weights of the proteins (tubulin and MAP's).
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