Heparin calcium (MW 3600-5000)

Heparin calcium (MW 3600-5000)

产品活性：Heparin (Nadroparin) calcium (MW 3600-5000) 是一种抗凝剂，可与抗凝血酶 III (ATIII) 可逆地结合，形成肝素-抗凝血酶 III 复合物。该复合物与凝血酶和其他活化的凝血因子 IX、X、XI 和 XII 结合并不可逆地使其失活，防止纤维蛋白原转化为纤维蛋白。

产品来源： www.medchemexpress.cn/heparin-calcium-mw-3600-5000.html

研究领域：Metabolic Enzyme/Protease | Autophagy | Anti-infection

作用靶点：Thrombin | Factor Xa | Autophagy | Bacterial

In Vitro: Heparin is a potent anticoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. Heparin and the structurally related Heparan Sulfate (Heparan Sulfate) are complex linear polymers comprised of a mixture of chains of different length, having variable sequences. Heparin interactes most tightly with peptides containing a complementary binding site of high positive charge density. Heparin and Heparan Sulfate predominantly exhibit linear helical secondary structures with sulfo and carboxyl groups displayed at defined intervals and in defined orientations along the polysaccharide backbone. Heparin resembles DNA as both are highly charged linear polymers that behave as polyelectrolytes. Heparin is believed to function as an anticoagulant primarily through its interaction with AT III by enhancing AT-III-mediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin binds to AT III and thrombin in a ternary complex, increasing the bimolecular rate constant for the inhibition of thrombin by a factor of 2000. Heparin is principally located in the granules of tissue mast cells that are closely associated with the immune response. Heparin makes numerous contacts with both FGF-2 and FGFR-1 stabilizing FGF–FGFR binding. Heparin also makes contacts with the FGFR-1 of the adjacent FGF–FGFR complex, thus seeming to promote FGFR dimerization.

In Vivo: Low-molecular-weight Heparin calcium (4 mg/kg; s.c. twice a day for 2 days) reduces the injury of skeletal muscle and the systemic inflammatory response in IRI SD rats.

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