PXS-4681A,1478364-87-2

PXS-4681A

产品活性：PXS-4681A 是一种有效、选择性、不可逆且具有口服活性的氨基脲敏感胺氧化酶 (SSAO; VAP-1) 抑制剂，Ki 为 37 nM。PXS-4681A 对相关的胺氧化酶、离子通道和七跨膜结构域受体显示出高度选择性。PXS-4681A 具有抗炎作用。

产品来源： www.medchemexpress.cn/pxs-4681a.html

研究领域：Neuronal Signaling

作用靶点：Monoamine Oxidase

In Vitro: PXS-4681A is an inhibitor of SSAO/VAP-1 in human, rat, mouse, rabbit, and dog species with IC50 values of 3 nM, 3 nM, 2 nM, 9 nM and 3nM, respectively.

In Vivo: PXS-4681A (2 mg/kg; PO; single dose) attenuates neutrophil migration, tumor necrosis factor-α, and interleukin-6 levels in mouse models of lung inflammation and localized inflammation.In rats, PXS-4681A is well absorbed with good bioavailability and oral half-life at the 10 mg/kg i.v. dose and the 20 mg/kg PO dose. Similarly, in BALB/C mice, PXS-4681A is well absorbed with good bioavailability and oral half-life at 2 mg/kg in both intravenous and oral studies.

相关产品：β-Aminopropionitrile | Rosmarinic acid | Tranylcypromine hemisulfate | Clorgyline hydrochloride | GSK-LSD1 dihydrochloride | Methylene Blue | Hypericin | Paeonol | Selegiline hydrochloride | Pargyline | (2-Chloropyridin-4-yl)methanamine hydrochloride | Phenelzine sulfate | Hydroxylamine hydrochloride | Moclobemide | Rasagiline | (E/Z)-J147 | PXS-5153A monohydrochloride | Lenumlostat | PXS-4728A | Iproniazid | Contezolid | Norharmane | OG-L002 | Vafidemstat | Safinamide | LOX-IN-3 | Simtuzumab