- ￥900 - 1450
- MedChemExpress(MCE)
- 美国
- HY-10858A
- 2025年12月05日
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- 库存：
货期：询盘
- 供应商：
MedChemExpress LLC
- 规格：
5 mg/10 mg
| 规格： | 5 mg | 产品价格： | ￥900.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥1450.0 |
产品活性：WAY 316606 hydrochloride 是一种分泌蛋白 sFRP-1 抑制剂，是分泌性糖蛋白 Wnt 的拮抗剂，在 FP 结合检测使用中，WAY-316606 作用于 sFRP-1 的 IC50 为 0.5 μM。
产品来源： www.medchemexpress.cn/way-316606-hydrochloride.html
研究领域：Stem Cell/Wnt
作用靶点：sFRP-1
In Vitro: The EC50 of WAY-316606 for Wnt-Luciferase Activity from U2-OS Cells is 0.65 μM. WAY-316606 binds to secreted frizzled-related protein (sFRP)-1 inhibitor with a KD of 0.08 μM and inhibits sFRP-1 with an EC50 of 0.65 μM. WAY-316606 also binds to sFRP-2, albeit over 10 times weaker with a KD of 1 μM. Using a fluorescence polarization binding assay that employs a fluorescent probe compound and purified human sFRP-1 protein in a competitive-binding format, the IC50 for WAY-316606 is 0.5 μM.
In Vivo: WAY-316606 increases bone formation when tested in a neonatal murine calvarial assay. WAY-316606 increases total bone area up to 60% in a dose-dependent manner with an EC50 of about 1 nM. WAY-316606 has good aqueous solubility, moderate to low inhibition of cytochrome p450 isozymes (3A4, 2D6, 2C9) and good stability in rat and human liver microsomes (t1/2>60 min in each species). In female Sprague-Dawley rats, WAY-316606 exhibits high plasma clearance (77 mL/min/kg, greater than hepatic blood flow) following a single intravenous bolus dose (2 mg/kg), which results in a rapid decline of drug exposure in the plasma despite the route of administration.
相关产品：WAY 316606
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