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- HY-163390
- 2025年12月05日
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RIP1 kinase inhibitor 9
产品活性：RIP1 kinase inhibitor 9 (compound SY-1) 是一种选择性的 RIP 激酶 (RIP kinase) 抑制剂。RIP1 kinase inhibitor 9 有效抑制癫痫引起的中枢炎症反应。RIP1 kinase inhibitor 9 抑制 Z-VAD-FMK (HY-16658B) 诱导的 HT-29 细胞坏死 (necroptosis)，EC50 为 7.04 nM。
产品来源： www.medchemexpress.cn/rip1-kinase-inhibitor-9.html
研究领域：Apoptosis
作用靶点：RIP kinase | Necroptosis
In Vitro: RIP1 kinase inhibitor 9 (10 nM, 4 h) effectively prevents the phosphorylation of both RIP1 and RIP3, hinders necrosome formation.
In Vivo: RIP1 kinase inhibitor 9 (5 mg/kg for p.o; daily for 7 days) suppresses inflammation in epileptic mice model.
相关产品：Necrostatin-1 | GSK-872 | Necrostatin 2 racemate | Bardoxolone | GSK2982772 | Sulfaphenazole | GSK583 | GSK-843 | RIP1/RIP3/MLKL activator 1 | Thioacetamide | GSK840 | WEHI-345 | GSK547 | RIPA-56 | PROTAC RIPK degrader-2 | GSK2983559 | GSK963 | Apostatin-1 | GSK2593074A | HS-1371 | GSK3145095 | Cholesteryl hemisuccinate | Eclitasertib | ICCB-19 hydrochloride | RIPK3-IN-1 | PROTAC RIPK degrader-6 | Chlorhexidine (digluconate)
产品活性：RIP1 kinase inhibitor 9 (compound SY-1) 是一种选择性的 RIP 激酶 (RIP kinase) 抑制剂。RIP1 kinase inhibitor 9 有效抑制癫痫引起的中枢炎症反应。RIP1 kinase inhibitor 9 抑制 Z-VAD-FMK (HY-16658B) 诱导的 HT-29 细胞坏死 (necroptosis)，EC50 为 7.04 nM。
产品来源： www.medchemexpress.cn/rip1-kinase-inhibitor-9.html
研究领域：Apoptosis
作用靶点：RIP kinase | Necroptosis
In Vitro: RIP1 kinase inhibitor 9 (10 nM, 4 h) effectively prevents the phosphorylation of both RIP1 and RIP3, hinders necrosome formation.
In Vivo: RIP1 kinase inhibitor 9 (5 mg/kg for p.o; daily for 7 days) suppresses inflammation in epileptic mice model.
相关产品：Necrostatin-1 | GSK-872 | Necrostatin 2 racemate | Bardoxolone | GSK2982772 | Sulfaphenazole | GSK583 | GSK-843 | RIP1/RIP3/MLKL activator 1 | Thioacetamide | GSK840 | WEHI-345 | GSK547 | RIPA-56 | PROTAC RIPK degrader-2 | GSK2983559 | GSK963 | Apostatin-1 | GSK2593074A | HS-1371 | GSK3145095 | Cholesteryl hemisuccinate | Eclitasertib | ICCB-19 hydrochloride | RIPK3-IN-1 | PROTAC RIPK degrader-6 | Chlorhexidine (digluconate)
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RIP1 kinase inhibitor 9
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