- ￥600 - 1900
- MedChemExpress(MCE)
- 美国
- HY-161343
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2373280-36-3
- 规格：
5 mg/10 mg/25 mg
| 规格： | 5 mg | 产品价格： | ￥600.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥950.0 |
| 规格： | 25 mg | 产品价格： | ￥1900.0 |
HDL-16
产品活性：HDL-16 是一种有效的 P2Y14R 拮抗剂，IC50 为 0.3095 nM。HDL-16 通过抑制肠上皮细胞 (IEC) 坏死性凋亡和保护粘膜屏障功能来改善 DSS (HY-116282C) 诱导的结肠炎。
产品来源： www.medchemexpress.cn/hdl-16.html
研究领域：GPCR/G Protein | Apoptosis
作用靶点：P2Y Receptor | Necroptosis
In Vitro: The N atom on benzoxazole ring of HDL-16 forms a hydrogen bond with Tyr102 residue, and the amine group also forms a hydrogen bond interaction with His184 residue in the binding pocket of P2Y14R. HDL-16 has almost no cytotoxicity under the concentration of 10 μM in HT-29 cells. HDL-16 can inhibit the necroptosis of HT-29 cells (with 20 ng/mL TNF‐α plus 20 μM z‐VAD‐fmk (HY-16658B) and Smac mimetic (BV6, 2 μM) for 8 h).
In Vivo: HDL-16 (10 μM or 20 μM; 100 μL; Rectally administered; daily; 6 days) with high-dose significantly suppresses colitis symptoms and leads to maintained gut barrier integrity in the mice.
相关产品：Bardoxolone | Ticagrelor | Clopidogrel | Sodium metatungstate | Uridine 5′-diphosphoglucose disodium salt | Sulfaphenazole | YM-254890 | MRS 2578 | Uridine-5'-diphosphate disodium salt | RIP1/RIP3/MLKL activator 1 | Cangrelor tetrasodium | PPTN hydrochloride | Uridine triphosphate trisodium salt | Thioacetamide | UDP-Galactose disodium | Apostatin-1 | Diquafosol tetrasodium | PSB-0739 | BPTU | Cholesteryl hemisuccinate | Prasugrel | AR-C118925XX | 2-Methylthio-AMP | Chlorhexidine (digluconate) | IM-54 | Necrostatin-7 | P2Y2R/GPR17 antagonist 1 | N6-(4-Hydroxybenzyl)adenosine
产品活性：HDL-16 是一种有效的 P2Y14R 拮抗剂，IC50 为 0.3095 nM。HDL-16 通过抑制肠上皮细胞 (IEC) 坏死性凋亡和保护粘膜屏障功能来改善 DSS (HY-116282C) 诱导的结肠炎。
产品来源： www.medchemexpress.cn/hdl-16.html
研究领域：GPCR/G Protein | Apoptosis
作用靶点：P2Y Receptor | Necroptosis
In Vitro: The N atom on benzoxazole ring of HDL-16 forms a hydrogen bond with Tyr102 residue, and the amine group also forms a hydrogen bond interaction with His184 residue in the binding pocket of P2Y14R. HDL-16 has almost no cytotoxicity under the concentration of 10 μM in HT-29 cells. HDL-16 can inhibit the necroptosis of HT-29 cells (with 20 ng/mL TNF‐α plus 20 μM z‐VAD‐fmk (HY-16658B) and Smac mimetic (BV6, 2 μM) for 8 h).
In Vivo: HDL-16 (10 μM or 20 μM; 100 μL; Rectally administered; daily; 6 days) with high-dose significantly suppresses colitis symptoms and leads to maintained gut barrier integrity in the mice.
相关产品：Bardoxolone | Ticagrelor | Clopidogrel | Sodium metatungstate | Uridine 5′-diphosphoglucose disodium salt | Sulfaphenazole | YM-254890 | MRS 2578 | Uridine-5'-diphosphate disodium salt | RIP1/RIP3/MLKL activator 1 | Cangrelor tetrasodium | PPTN hydrochloride | Uridine triphosphate trisodium salt | Thioacetamide | UDP-Galactose disodium | Apostatin-1 | Diquafosol tetrasodium | PSB-0739 | BPTU | Cholesteryl hemisuccinate | Prasugrel | AR-C118925XX | 2-Methylthio-AMP | Chlorhexidine (digluconate) | IM-54 | Necrostatin-7 | P2Y2R/GPR17 antagonist 1 | N6-(4-Hydroxybenzyl)adenosine
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HDL-16,2373280-36-3
￥600 - 1900
