α-Glucosidase-IN-57

α-Glucosidase-IN-57

产品活性：α-Glucosidase-IN-57 (Compound 10c) 是一种具有竞争性和口服活性的 α-glucosidase 抑制剂， IC50 值为 0.180 μM，Ki 为 0.15 μM。α-Glucosidase-IN-57 能降低小鼠空腹和总体血糖水平，可用于抗糖尿病的研究。

产品来源： www.medchemexpress.cn/α-glucosidase-in-57.html

研究领域：Metabolic Enzyme/Protease

作用靶点：Glucosidase

In Vitro: α-Glucosidase-in-57 (Compound 10c) (0, 0.045, 0.09, 0.18 μM) competes with the substrate p-NPG (HY-W039892) (1-16 μM) for the same active site of the α-Glucosidase enzyme. α-Glucosidase-IN-57 acts as a potent competitive inhibitor of alpha-glucosidase.

In Vivo: α-Glucosidase-IN-57 (Compound 10c) (250, 500, 1000 mg/kg; Oral gavage (p.o.); 72h) is well tolerated and safe in Wistar albino rat models.α-Glucosidase-IN-57 (10, 25, 50 mg/kg; Oral gavage (p.o.); once daily for 28 days) has hypoglycemic activity in a Wistar albino rat model of diabetes, including reduces fasting blood glucose levels, improves glucose tolerance, and possibly improves islet structure of pancreatic tissue.

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