12-OAHSA,101901-73-9

12-OAHSA

产品活性：12-OAHSA 是橄榄油的一种成分。12-OAHSA 具有口服活性，可改善胰岛素抵抗肥胖小鼠的葡萄糖稳态。

产品来源： www.medchemexpress.cn/12-oahsa.html

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: 12-OAHSA (25 μM, 24 h) inhibits LPS-induced IL-1b, IL-6, Nos2, and Tnf-α in Raw 264.7 macrophages.12-OAHSA (25 μM, 6 h) reduces IKKβ phosphorylation and increases phosphorylation of p65 in Raw 264.7 macrophages.

In Vivo: 12-OAHSA (30 mg/kg, p.o., for 10 d) inhibits obesity-induced insulin resistance in HFD induced obese C57BL/6 mice.

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