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- 2025年12月05日
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c-Met-IN-23
产品活性：c-Met-IN-23 (Compound 12g) 是一种 c-Met 抑制剂 (对 c-Met 的 IC50 为 0.052 μM)。c-Met-IN-23 还抑制癌性 HepG2 和 BxPC3 细胞中的 MDR1 和 MRP1/2 泵。c-Met-IN-23 是一种抗癌剂。
产品来源： www.medchemexpress.cn/c-met-in-23.html
研究领域：Protein Tyrosine Kinase/RTK | Membrane Transporter/Ion Channel
作用靶点：c-Met/HGFR | P-glycoprotein
In Vitro: c-Met-IN-23 (72 h) inhibits HGF-induced cell proliferation, with IC50s of 12.4, 3.06, 19.30, 16.85 µM for HT29, HepG2, MCF7, MDA-MB-231 cells respectively.c-Met-IN-23 (0.3-150 µM, 30 min) blocks P-gp and MRP1/2 pumps in both HepG2 and BxPC3 cells.c-Met-IN-23 (3 µM, 24 h) increases the expression of P-gp in HepG2 and BxPC3 cells, as well as MRP1 and MRP2 in BxPC3 cells, and inhibits the P-gp-mediated efflux in HepG2 cell.
相关产品：Afatinib | Crizotinib | Cabozantinib | Verapamil | Capmatinib | Elacridar | Tariquidar | Glibenclamide | Savolitinib | Foretinib | Zosuquidar trihydrochloride | Piperine | Risperidone | CP-100356 hydrochloride | Tivantinib | Limonin | BMS 777607 | Trifluoperazine dihydrochloride | Merestinib | PHA-665752 | Valspodar | SU11274 | Amuvatinib | JNJ-38877605 | Telisotuzumab vedotin
产品活性：c-Met-IN-23 (Compound 12g) 是一种 c-Met 抑制剂 (对 c-Met 的 IC50 为 0.052 μM)。c-Met-IN-23 还抑制癌性 HepG2 和 BxPC3 细胞中的 MDR1 和 MRP1/2 泵。c-Met-IN-23 是一种抗癌剂。
产品来源： www.medchemexpress.cn/c-met-in-23.html
研究领域：Protein Tyrosine Kinase/RTK | Membrane Transporter/Ion Channel
作用靶点：c-Met/HGFR | P-glycoprotein
In Vitro: c-Met-IN-23 (72 h) inhibits HGF-induced cell proliferation, with IC50s of 12.4, 3.06, 19.30, 16.85 µM for HT29, HepG2, MCF7, MDA-MB-231 cells respectively.c-Met-IN-23 (0.3-150 µM, 30 min) blocks P-gp and MRP1/2 pumps in both HepG2 and BxPC3 cells.c-Met-IN-23 (3 µM, 24 h) increases the expression of P-gp in HepG2 and BxPC3 cells, as well as MRP1 and MRP2 in BxPC3 cells, and inhibits the P-gp-mediated efflux in HepG2 cell.
相关产品：Afatinib | Crizotinib | Cabozantinib | Verapamil | Capmatinib | Elacridar | Tariquidar | Glibenclamide | Savolitinib | Foretinib | Zosuquidar trihydrochloride | Piperine | Risperidone | CP-100356 hydrochloride | Tivantinib | Limonin | BMS 777607 | Trifluoperazine dihydrochloride | Merestinib | PHA-665752 | Valspodar | SU11274 | Amuvatinib | JNJ-38877605 | Telisotuzumab vedotin
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c-Met-IN-23
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