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文献和实验It is bad practice to maintain a cell line in continuous or extended culture for the following reasons: * Risk of microbial contamination *Loss of characteristics of interest (i.e. surface antigen or monoclonal antibody expression) *Genetic
Mouse Strains and Genetic Nomenclature
characteristics and peculiarities of the different strains and stocks of laboratory animals from the genetic point of view. We explain how they are produced and maintained as well as their advantages and disadvantages in the context of animal experiments
Production of Zebrafish Germline Chimeras from Cultured Cells
where they participate in normal development and contribute to the germ cell lineage. When sexually mature, the germline chimeric animal possesses eggs or sperm derived from ES cells, making it possible to pass the genetic alteration on to subsequent generations
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