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文献和实验Lung-Specific Expression of Mutant p53 as Mouse Model for Lung Cancer
, there has been a concomitant change in the histologic type of lung cancer (4) . While SCLC has persisted at about 20%, adenocarcinoma has increased to 45% with declines in squamous cell and large cell carcinoma. Thun and colleagues (5) have suggested that these changes
Tumor Suppressor Genes in Lung Cancer
% of bronchogenic carcinomas, and the remaining tumors, non-small-cell lung cancers (NSCLC). SCLC cells possess neuroendrocrine-like properties, whereas most NSCLC lack these functions and can be divided into three major subtypes, adenocarcinoma, squamous cell
Mutations in the K-ras oncogene and mutations or deletions in the tumor suppressor gene p53 are the two most prevalent oncogenetic alterations in human lung cancer. Ras mutations occur primarily in lung adenocarcinomas and small numbers
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