重组人Dickkopf相关蛋白1（DKK-1）

重组人Dickkopf相关蛋白1(DKK-1) - PRP1079

产品核心参数

• 产品分类：细胞因子及蛋白核心产品
• 应用领域：细胞培养体系中的Wnt/β-Catenin信号通路研究
• 表达系统：大肠杆菌表达系统，未添加任何融合标签
• 结构特征：包含Thr32-His266结构域(UniProt:O94907)

质量验证数据

• 纯度：经SDS-PAGE验证＞98%单一条带
• 内毒素：＜1 EU/μg(LAL法测定)
• 分子量：25.8 kDa(与实际检测误差±10%)

产品规格及供应

• ▪ 10μg | ¥588 | 次日发货
• ▪ 50μg | ¥1498 | 次日发货
• ▪ 500μg | 请咨询报价
• ▪ 1mg | 批量定制服务

操作规范

• 复溶要求：推荐使用配套缓冲液(浓度≥100μg/mL)
• 保存方案：-20℃保存冻干粉(有效期12个月)；复溶后4℃保存≤7天
• 稳定性处理：建议添加载体蛋白(BSA/HSA)后分装冻存

技术背景

人源DKK-1作为Wnt信号通路关键调控因子，通过结合LRP-6受体与Kremen 2形成三元复合物，在骨代谢调控与肿瘤微环境研究中具有重要价值。该蛋白具有双功能特性：既可抑制原发肿瘤生长，又可能促进转移进程。

关键警示

• ⚠ 本产品仅限科研使用，严禁用于临床诊断
• ⚠ 使用前需结合具体实验体系优化浓度参数
• ⚠ 专利应用风险需由使用者自行评估

完整蛋白序列信息请访问UniProt数据库：
https://www.uniprot.org/uniprotkb/O94907/entry

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注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

Recombinant Human Dickkopf-related protein 1 (DKK-1) - PRP1079

Core Product Parameters

• Product Category: Core Cytokine & Protein Products
• Application: Wnt/β-Catenin signaling pathway research in cell culture systems
• Expression System: E. coli expression system, no fusion tag
• Structural Feature: Contains Thr32-His266 domain (UniProt:O94907)

Quality Validation Data

• Purity: >98% single band by SDS-PAGE
• Endotoxin: <1 EU/μg (LAL assay)
• Molecular Weight: 25.8 kDa (±10% measurement variation)

Product Specifications & Supply

• ▪ 10μg | ¥588 | Next-day delivery
• ▪ 50μg | ¥1498 | Next-day delivery
• ▪ 500μg | Contact for quotation
• ▪ 1mg | Bulk customization service

Operation Guidelines

• Reconstitution: Recommended buffer (concentration ≥100μg/mL)
• Storage: Lyophilized powder at -20℃ (12-month shelf life); ≤7 days at 4℃ after reconstitution
• Stability Treatment: Recommend adding carrier protein (BSA/HSA) before aliquot freezing

Technical Background

Human DKK-1, as a key regulator of Wnt signaling pathway, forms ternary complexes with LRP-6 receptor and Kremen 2, demonstrating significant value in bone metabolism regulation and tumor microenvironment research. This protein exhibits dual functionality: inhibiting primary tumor growth while potentially promoting metastasis.

Critical Notices

• ⚠ For research use only. Not for clinical diagnosis.
• ⚠ Concentration optimization required for specific experimental systems
• ⚠ Patent application risks to be assessed by end users

Complete protein sequence information available at UniProt database:
https://www.uniprot.org/uniprotkb/O94907/entry

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Note: Above information may change due to product optimization. Please contact AcroBiosystems for updated details.