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- bsm-60016R
- 2025年10月24日
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50ul/100ul/25ul
| 规格： | 50ul | 产品价格： | ￥1400.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2500.0 |
| 规格： | 25ul | 产品价格： | ￥800.0 |
| 产品编号 | bsm-60016R |
| 英文名称 | MUC2 Recombinant Rabbit mAb |
| 中文名称 | 粘蛋白-2/上皮膜抗原2重组兔单抗 |
| 英文别名 | MLP; SMUC; Intestinal mucin 2; MUC 2; Mucin 2; Mucin 2 intestinal; Mucin 2 intestinal/tracheal; Mucin 2 oligomeric mucus/gel forming; Mucin 2 precursor; Mucin 2 tracheal; Mucin like protein; Mucin2; Intestinal mucin-2; MUC-2; Muc2; MUC2_HUMAN; Mucin-2; Mucin2. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1:50-100 Not yet tested in other applications. |
| 交叉反应 | Human, Rat, human colon carcinoma, human colon carcinoma, human colon carcinoma, human colon carcinoma, colon, colon, colon, colon, Human duodenum, Human duodenum, Human duodenum, Human duodenum |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human MUC2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 理论分子量 | 570 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Extracellular matrix > MUC Cancer > Tumor immunology > Tumor-associated antigens Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > MUC Tags & Cell Markers > Cell Type Markers > Tumor Associated |
| 亚基 | Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked. |
| 亚细胞定位 | Secreted. Note=In the intestine, secreted into the inner and outer mucus layers. |
| 组织特异性 | Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder. |
| 翻译后修饰 | O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria. At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway. |
| 相似性 | Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 TIL (trypsin inhibitory-like) domain. Contains 2 VWFC domains. |
| 功能 | Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {Flow-Cyt} | {1:50-100} |
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文献和实验[IF={{ 7.7 }}] {Bingbing Guo. et al.β-1,3-glucans from Euglena Gracilis protects against ulcerative colitis via modulating the gut barrier, T-cell immunity and gut microbiota.international journal of biological macromolecules.2025 Feb 19;305(Pt 2):141288.} {Western blot} {Mouse}
[IF={{ 6.1 }}] {Xueran Mei. et al. Maternal Phlorizin Intake Protects Offspring from Maternal Obesity-Induced Metabolic Disorders in Mice via Targeting Gut Microbiota to Activate the SCFA-GPR43 Pathway. J AGR FOOD CHEM. 2024;XXXX(XXX):XXX-XXX} {IF} {Mouse}
[IF={{ 5.988 }}] {Yang Liu. et al. Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of "the lung and intestine are related". FRONT PHARMACOL. 2022 Sep 7;13:927384} {IHC} {Rat}
[IF={{ 3.829 }}] {Wang Ruibiao. et al. Effects of exosomes derived from Trichinella spiralis infective larvae on intestinal epithelial barrier function. VET RES. 2022 Dec;53(1):1-11} {WB} {Pig}
[IF={{ 2.9 }}] {Hong-Yun Nie. et al. Moxifloxacin plus Cordyceps polysaccharide ameliorate intestinal barrier damage due to abdominal infection via anti-inflammation and immune regulation under simulated microgravity. LIFE SCI SPACE RES. 2024 Nov;:} {WB,IHC} {Rat}
到 PVDF 膜上，同时减少蛋白不必要降解，这对于最终获得清晰、可信结果也是需要考虑因素。抗体信息：1.ACC1, Recombinant Rabbit monoclonal IgG. HuaAn. HuaAn biotechnology , inc.2.ATGL, Mouse mAb IgG1, Cat#:RT1058. HuaAn biotechnology , inc.3.p-PERK(Thr981), Rabbit Polyclonal IgG primary antibodies, Cat
细胞数目及细胞活力，一定范围内信号强度和ATP 含量成正比 Estrogen Receptor alpha Antidiv (YA450) (HY-P80663) www.medchemexpress.cn/antibody/estrogen-receptor-alpha-rabbit-mab.html 可用于乳腺癌组织的免疫组化分析 C-erbB-2/HER2 Antidiv (YA771) (HY-P80658) www.medchemexpress.cn/antibody/erbb-2-1c4
The OP9-DL1 System: Generation of T-Lymphocytes from Embryonic or Hematopoietic Stem Cells In Vitro
al. 2006b ). MATERIALS Reagents Anti-CD24 monoclonal antibody (mAb) (J11d clone) (for Protocol 3) Use either culture supernatant that contains anti-CD24 mAb or purified anti-CD24 mAb (see Step 55). BDPharmLyse (red blood cell lysing
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