- ￥9086
- Biorbyt
- 英国
- orb1785911
- 2025年07月12日
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- 详细信息
- 技术资料
- 保存条件：
详询
- 保质期：
6-12个月
- 英文名：
SRX3305
- 库存：
99
- 供应商：
Biorbyt
- CAS号：
[2409965-28-0]
- 规格：
5 mg
SRX 3305 is a potent, triple BTK/PI3K/BRD4 inhibitor with IC50 of 6.5 nM, 15 nM, and 4 nM toward BTK, PI3Kɑ and PI3Kδ respectively, inhibits BRD4 BD1 and BD2 with IC50 of 77 and 95 nM.SRX3305 showed enhanced binding to the drug-resistant C481S mutant of BTK compared to SRX-3262 (IC50=9 uM and 25 uM, respectively).SRX3305 displayed cytotoxicity aginst MCL cell lines JeKo-1, Mino, Granta with IC50 of 58 nM, 1 nM, 1.1 uM, respectively.SRX3305 inhibited cell vbiability of JeKo-1 BTK C481S and Mino BTK C481S mutant cell lines with IC50 of 1 uM and 47 nM, respectively, with minimally toxic to healthy donor PBMCs.SRX3305 showed improved efficacy in MCL and Ibrutinib-resistant MCL cells, SRX3305 impacted gene expression, perturbs the cell cycle and promotes apoptosis in MCL.
产品名：SRX3305
货号：orb1785911
产品中文名：SRX3305
产品详情链接：https://www.biorbyt.com/srx3305-orb1785911.html
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SRX3305，orb1785911，Biorbyt
￥9086
