- ￥11693
- Biorbyt
- 英国
- orb1786001
- 2025年07月11日
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- 详细信息
- 技术资料
- 保存条件：
详询
- 保质期：
6-12个月
- 英文名：
N8279
- 库存：
99
- 供应商：
Biorbyt
- 规格：
5 mg
N8279 (NCATS-SM8864) is a selective, brain-penetrant small molecule Gαq-biased GHSR1a agonist with binding IC50 of 1.3 uM.N8279 is nearly an order of magnitude (8.9-fold) more potent than the endogenous ligand ghrelin and is a full agonist.iCa2+ EC50 of N8279 is 41-fold more potent than its GHSR1a binding IC50, suggesting possible allosteric activity, which could be competitively inhibited by GHSR1a antagonists YIL781 and JMV2959.N8279 is a weak activator of GHSR1a-mediated, βarr2-dependent cellular responses relative to ghrelin.N8279 requires receptor sites and/or conformational states driven by the GHSR1a ECD that are distinct from ghrelin.N8279 is brain-penetrant and attenuates aberrant DAergic behavior in mice.
产品名：N8279
货号：orb1786001
产品中文名：N8279
产品详情链接：https://www.biorbyt.com/n8279-orb1786001.html
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N8279，orb1786001，Biorbyt
￥11693
