Noggin is an extracellular cysteine knot protein that plays a crucial role in vertebrate dorsoventral patterning. Noggin binds and inhibits the activity of bone morphogenetic proteins (BMPs) via a conserved N-terminal clip domain. Noggin binds in vitro to most BMPs with no apparent dissociation, which suggests that the concentration of active ligand would be effectively decreased for all BMPs that it targets. Noggin was first described in the African Clawed Frog Xenopus laevis, where it is secreted from Spemann’s organizer and antagonizes BMP signaling. This activity generates a morphogen gradient along the dorsal-ventral axis, causing prospective ventral mesoderm to become dorsal mesoderm (dorsalization) and prospective epidermis to become neuroectoderm.
产品名:Recombinant Human Noggin
货号:orb1921825
产品中文名:Recombinant Human Noggin 蛋白
产品详情链接:https://www.biorbyt.com/recombinant-human-noggin-orb1921825.html