- ￥7631 - 44265
- Biorbyt
- 英国
- orb1806493
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- 保质期：
6个月
- 英文名：
Mouse IL-6 R alpha / CD126 Protein, Fc Tag (MALS verified)
- 库存：
99
- 供应商：
Biorbyt
- 规格：
100 ug/1 mg
| 规格： | 100 ug | 产品价格： | ￥7631.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥44265.0 |
Interleukin 6 receptor (IL6R) is also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit also shared by many other cytokines. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases. Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.
产品名：Mouse IL-6 R alpha / CD126 Protein, Fc Tag (MALS verified)
货号：orb1806493
产品中文名：Mouse IL-6 R alpha / CD126 Protein, Fc Tag (MALS verified) 蛋白
产品详情链接：https://www.biorbyt.com/mouse-il-6-r-alpha-cd126-pro-orb1806493.html
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文献和实验Capture and Qualitative Analysis of the Activated Fc Receptor Complex from Live Cells
Bajno, L., Peng, X.R., Schreiber, A.D., Moore, H.P., Trimble, W.S., and Grinstein, S. 2000. Focal exocytosis of VAMP3‐containing vesicles at sites of phagosome formation. J. Cell Biol. 149:697‐706.
Site‐Specific Protein Labeling with SNAP‐Tags
Gautier, A., Juillerat, A., Heinis, C., Correa, I.R., Jr., Kindermann, M., Beaufils, F., and Johnsson, K. 2008. An engineered protein tag for multiprotein labeling in living cells. Chem. Biol. 15:128–136
氨基酸残基数约为50～60，有7个β折叠股，这种结构介于V组和C1组之间，如CD3γ、δ和ε链，CD2和LFA-3（CD58），pIgR靠近胞膜结构域，FcγRⅠ、FcγRⅡ、FcγRⅢ、FcεRⅠα链、FcαR、ICAM-1，CEA第2至7个结构域，IL-6R、M-CSFR、G-CSFR、M-MAG、SCFR、PDGFR第1至4个结构域，与神经系统相关的分子N-CAM、N
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