Amyloid Beta Peptide 1-42 Mono

mers 蛋白，orb1714194，biorbyt

价格￥4420

品牌biorbyt
产地英国
货号orb1714194
更新日期2025年12月16日

武汉博欧特生物科技有限公司

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详细信息
文献和实验
技术资料

保存条件：
-80°C
保质期：
6个月
英文名：
Amyloid Beta Peptide 1-42 Monomers
库存：
详询客服
供应商：
biorbyt
规格：
100 ug

产品描述：Human Synthetic Amyloid Beta Peptide 1-42 (HFIP treated) Monomers

产品别名：Abeta Protein, Abeta peptide, Amyloid beta peptide, Beta amyloid peptide, amyloid beta precursor protein peptide, APP

验证过的应用：In vitro, In vivo, WB

应用笔记：Certified >98% pure using mass spec and HPLC.

反应种属：Human

纯度：>98%

生物来源：Human

蛋白序列：DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

分子量：4.5 kDa

标签：No Tag

防腐剂：Dry powder. See "Other Resources" for re-suspension instructions/protocol.

来源：Synthetic

浓度：N/A - dried peptide film

Uniprot ID：P05067

Note：For research use only.

Western blot of amyloid beta 1-42 monomers, oligomers and fibrils using anti-amyloid beta 6E10 antibody. Amyloid beta constructs at 160 pmol were run on 4-12% Bis-Tris SDS-PAGE, transferred to nitrocellulose in the presence of 0.02% v/v Tween-20, and blotted with 1:1000 mouse 6E10 primary antibody (Biolegend). Oligomers observed under TEM/AFM show distinct dimer/trimer bands as well as a signal from ~37-75 kDa (middle). Fibrils observed under TEM/AFM show a signal greater than 100 kDa and a distinct signal in the stacking gel (right).

TEM of amyloid beta 1-42 monomers, oligomers and fibrils . Negative stain transmission electron microscopy images acquired at 80 Kv on carbon coated 400 mesh copper grids using phosphotungstic acid and uranyl acetate stain. Scale bar = 100 nm.

AFM of amyloid beta 1-42 monomers, oligomers and fibrils . Atomic force microscopy analysis of 1.0 mg/mL samples diluted to 0.1 mg/mL in dH2O, mounted on freshly cleaved mica, washed, dried and analyzed with tapping mode. Representative images are 2.5 x 2.5 μm x-y with a z-range of 10 nm.

Amyloid beta 1-42 oligomers and fibrils show a dose-dependent toxicity to primary rat cortical neurons, but not monomers. Survival of rat primary cortical neurons 14 days after treatment with different concentrations of (A) monomers, (B) oligomers or (C) fibrils quantified by MAP2 positive neurons and expressed as a percentage of control. Fibrils and respective vehicle controls were initially sonicated in a Bioruptor. Test conditions were run in the same plate as untreated control and vehicle controls, which consisted of buffer without amyloid beta 1-42 protein. Data expressed as mean +/- s.e.m. (n=6).

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文献和实验

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Evaluating Amyloid Beta (A) 1-40 Degradation by Capillary Electrophoresis
Here, we describe a capillary electrophoresis method for evaluating proteolysis of the amyloid beta peptide (Aβ) 1–40. This method is suitable for kinetic studies, demands little specialized equipment, and consumes only small
Interaction of the Presenilins with the Amyloid Precursor Protein (APP)
the deposition of amyloid Aβ peptide. The latter is released from its cognate amyloid precursor protein (APP) by a two-step proteolytic conversion: first, proteolysis of APP by β-secretase, which releases the N-terminus of Aβ, and second, conversion
Activating the NLRP3 Inflammasome Using the Amyloidogenic Peptide IAPP
an inflammasome complex that ultimately cleaves pro-IL-1β and pro-IL-18 into their mature, secreted forms. Here we describe a protocol by which one type of amyloidogenic peptide, islet amyloid polypeptide (IAPP, otherwise known as amylin) can be prepared and used

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Amyloid Beta Peptide 1-42 Monomers 蛋白，orb1714194，biorbyt

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GALNAC4S-6ST Peptide - middle region 蛋白，orb2015315，Biorbyt

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