相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
PD-L1 Antibody 抗体
- 抗体英文名:
PD-L1 Antibody
- 浓度:
详询
- 应用范围:
IHC
- 宿主:
Rabbit
- 适应物种:
Human
- 保质期:
6-12个月
- 抗原来源:
详询
- 目录编号:
orb1945533
- 级别:
科研
- 库存:
99
- 供应商:
Biorbyt
- 标记物:
Unconjugated
- 克隆性:
MONOCLONAL
- 保存条件:
Store at 2-8°C. To ensure stability, immediately replace vial back in the refrigerator after each use
- 形态:
详询
- 亚型:
IgG
- 免疫原:
详询
- 规格:
7 ml
Programmed Death-Ligand 1 (PD-L1), CD274, or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumour cells resistant to lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumour aggressiveness and risk of death. When considered in adjunct with CD8+ tumour-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small-cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.
产品名:PD-L1 Antibody
货号:orb1945533
产品中文名:PD-L1 Antibody 抗体
产品详情链接:https://www.biorbyt.com/pd-l1-antibody-orb1945533.html
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验「神药」再显威!杨黄浩等让二甲双胍扮演 PD-L1 「单抗」角色,提高治疗效果
以 PD-1/PD-L1 为代表的免疫检查点抑制剂(Immune Checkpoint Blockades, ICBs)在实体瘤中「大杀四方」,取得了传统治疗方法未有的良好疗效,逐渐成为了继手术、放疗、化疗、靶向治疗后又一种重要的肿瘤治疗手段。然而,免疫检查点抑制剂在实体瘤中的总体有效率依然仅有 20-30%。目前的 PD-1/PD-L1 等抗体类药物治疗依然存在着一些不可避免的问题, 如致命的免疫相关不良事件 (irAE)、复杂的生产工艺、高昂的成本等。此外,基于抗体的 ICBs 通过构象
【进展|热点】Nature Immunology: 让T细胞动起来
, as antibody blockade of PD-1 or PD-L1 resulted in lower T cell motility, enhanced T cell–DC contacts and caused autoimmune diabetes. Blockade of the immunomodulatory receptor CTLA-4 did not alter T cell motility or abrogate tolerance. Thus, PD-1–PD-L1
中科院高福院士课题组 2020 年发表了哪些重要的研究成果?
的主要靶标。2020 年 3 月 11 日,高福院士联合逯光文在 Cell Host & Microbe 发文:Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody。该研究报告了狂犬病毒 RABV-G 的晶体结构,分别在〜pH-8.0 时以游离形式和在〜pH-6.5 时与中和抗体
技术资料暂无技术资料 索取技术资料











