- ￥5265
- Biorbyt
- orb1823274
- 英国
- 2025年06月19日
- IHC-P
- Rabbit
- Human
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- 详细信息
- 技术资料
- 抗体名：
TIM-3 Antibody / HAVCR2 抗体
- 抗体英文名：
TIM-3 Antibody / HAVCR2
- 浓度：
详询
- 应用范围：
IHC-P
- 宿主：
Rabbit
- 适应物种：
Human
- 保质期：
6-12个月
- 抗原来源：
详询
- 目录编号：
orb1823274
- 级别：
科研
- 库存：
99
- 供应商：
Biorbyt
- 标记物：
Unconjugated
- 克隆性：
RECOMBINANT
- 保存条件：
Aliquot the TIM-3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
- 形态：
详询
- 亚型：
Rabbit IgG, kappa
- 免疫原：
A recombinant fragment of human TIM3 protein (within amino acids 1-200) was used as the immunogen for the TIM-3 antibody.
- 规格：
20 ug
TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+ Th1 and CD8+ Tc1) but not on helper T cells (CD4+ Th2 and CD8+ Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
产品名：TIM-3 Antibody / HAVCR2
货号：orb1823274
产品中文名：TIM-3 Antibody / HAVCR2 抗体
产品详情链接：https://www.biorbyt.com/tim-3-antibody-havcr2-orb1823274.html
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TIM-3 Antibody / HAVCR2 抗体，orb1823274，Biorbyt
￥5265
