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文献和实验Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families
at an excitation wavelength of 370 nm and an emission wavelength of 450 nm. This method is applicable to enzymatic studies to determine the catalytic activity of cDNA-expressed human enzymes in the CYP1, CYP2, and CYP3 families, and 7-ethoxycoumarin O -deethylation
Use of 7-Ethoxycoumarinto Monitor Multiple Enzymesin the Human CYP1, CYP2, and CYP3 Families
in the human CYP1, CYP2, and CYP3 families are active catalysts of 7-ethoxycoumarin O-deethylation (3 ). Consequently, the 7-ethoxycoumarin O-deethylase assay has been used to verify the catalytic activity of a panel of recombinant human P450s in the CYPl, CYP
PLoS Genet. 2009 March; 5 (3) : e1000433. Published online 2009 March 20. doi: 10.1371/journal.pgen.1000433 A Genome-Wide Association Study Confirms VKORC1 , CYP2C9 , and CYP4F2 as Principal Genetic
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